ctu2-b

Gene

ctu2-b

Protein

Cytoplasmic tRNA 2-thiolation protein 2-B

Organism

Xenopus laevis

Length

512 amino acids

Function

Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ctu1/atpbd3 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position.

Similarity

Belongs to the CTU2/NCS2 family.

Mass

57.315 kDa

Sequence

MCEEGETYCPEVKDAKQAKSLGKICMKCKESSAALLIRAGDAFCKSCFKEYFVHKFRATLGKNRVIYPGEKVLLAYSGGPSSSAMVRQVQEGLSRDAPKKLRFVPGILFIDEGTACGMSWEERQQILSEICSVLQQTKIPFHIVSLEQVFSLPGSVLQRGAPEQRPNYKEEVDRFLVQEREQGDAGCSEMLERLEVTDSDSPGSSDKMYQSTCSRPPDMHTQKLKQLFASAKTLTAKQQLLHTLRSHLILHIARTCGYSKVMTGESCTRLSIRLLSNVSLGRGAFLPLDTGFCDSRYGDVDIIRPMREYSSKEIAYYNRFFNVLPIFIPALDTKASENSSIQHLTEVFVNRLQADFPSTVSTLYRTSEKLNVSIIDADQETCAKDRCLLCLSPLDTQAGKASAFSATQLSHHLSQKIPMKSNDLANNSDKSCCQGGQGCKEAGYGDTCQSRALQTPSFVHMLCYSCRLTVKDMQSLDVLPQYVLHEAEYRCHRTEMRKEIQEFLLEEDDGDS

Protein

Cytoplasmic tRNA 2-thiolation protein 2-B: ctu2-b