Protein
FACT complex subunit ctc-2
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
Similarity
Belongs to the peptidase M24 family. SPT16 subfamily.
Sequence
MADIKIDSKVFQERVSHFYNAWKADKRSGDALFGGVSSIVILMGKVDENPEFHKNNAIHFWLLGYEFPTTLMLFTLDTIYILTTQKKAKYLDQVKGGRYPVEVLVRGKDAAENEKLFIKITDAIKAAGKKVGVLTKDTSKGPFIDEWKKVYADNCKDVEEVDVAQALSAGAFSVKDETELRAMRTSSKACVALLTPYFLDEMSNILDQDKKIKHSALADKVFNKLEDDKFWKTVELPNRQKLPADLDPEQLDWILGPIVQSGGKFDLKWQADSDNDILHPGIIIAAMGLRYKSYCSQIARTFMVDPNKSQESNYKFLLAVHNLILKEIRDGAIVKDVYTKAYNFVRSKKPDLEKHFLKNVGFGIGLENKDPTLILNNKNTRTLKDGMTLVVTTGFSDIQNPNPQDKNSKVYSLILSDTIRVTSSEPVVFTGEAPVDVDATSFFFKDEEEAQPTPKKEKRDSRVGAVATKNITSTRLRSERNTTVDEDADKRRREHQKELAQKKQKEGLAKYAESTADENGVEIKKFKRFESYKRDNQFPPKVKDMGIVIDQKNATIVLPVMGRPVPFHINTIKNASKSDEGEWSFLRINFLSPGQGVGRKDEQPFEDASAHFVRSLTFKSTDGDRYADIANQISNLKRDAVKKEQEKKDMEDVVEQDKLVEIRNRRPAVLDNVFIRPAMEGKRVPGKVEIHQNGIRYQSPLSTTQRVDILFSNVRHLFFQPCQHELIVIIHIHLKDPIIIGNKKKTKDVQFYREATDIQFDETGNRKRKYRYGDEDEFEAEQEERRRRAELDRLFKSFAEKIAEAGRNEGIEVDMPLRDLGFNGVPFRSNVYIQPTTECLIQITEPPFMVITLEDIEVAHLERVQFGLKNFDLVFVFKDFTRPPYHINTIPVESLEDVKEFLDSSDIAFSEGPLNLNWGVIMKTVTANTHQFFLDGGWGFLQNDSDDDEVEEEEEESAFEIDESELEDASESSEEDSEYDSNASEEASDEAEDSEEEEGEDWDELERKAKKRDRESGFDDEEERAAPKKRRK