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csp-3

Gene
csp-3
Protein
Non-catalytic caspase homolog csp-3
Organism
Caenorhabditis elegans
Length
139 amino acids
Function
Non-catalytic caspase homolog which does not contain the region necessary for caspase activity (PubMed:9857046). Acts as an inhibitor of caspase ced-3 zymogen autoactivation and delays ced-4-induced ced-3 processing (PubMed:18776901). Has no effect on active ced-3 (PubMed:18776901). Probably by preventing ced-3 activation, protects cells, whose fate is to live, from apoptosis during embryonic and larval development (PubMed:18776901).
Similarity
Belongs to the peptidase C14A family.
Mass
16.44 kDa
Sequence
MFFGKLGGFAFFLQRAVRCDGFIDNFFDRIPKFFQFMKSKFPSHQTSSSQADLLVSFSTSPGFLSFKDETKDTWYIQELYRVIIENAKDTHLADLLTETNRRVVEKYEADKVVFVCKQAPEFWSRFTKQLFFMSRNDVF