About Products Protein Database Contact

csn6

Gene
CSN6
Protein
COP9 signalosome complex subunit 6
Organism
Drosophila melanogaster
Length
341 amino acids
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.
Similarity
Belongs to the peptidase M67A family. CSN6 subfamily.
Mass
38.306 kDa
Sequence
MEQMEVDVDMSAKPSTSSSAAAGSSMAVDKTADQNPQPQGNIMAAAGTSGSVTISLHPLVIMNISEHWTRFRAQHGEPRQVYGALIGKQKGRNIEIMNSFELKTDVIGDETVINKDYYNKKEQQYKQVFSDLDFIGWYTTGDNPTADDIKIQRQIAAINECPIMLQLNPLSRSVDHLPLKLFESLIDLVDGEATMLFVPLTYTLATEEAERIGVDHVARMTSNESGEKSVVAEHLVAQDSAIKMLNTRIKIVLQYIRDVEAGKLRANQEILREAYALCHRLPVMQVPAFQEEFYTQCNDVGLISYLGTLTKGCNDMHHFVNKFNMLYDRQGSARRMRGLYY

Gene
CSN6
Protein
COP9 signalosome complex subunit 6
Organism
Oryza sativa subsp. japonica
Length
329 amino acids
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and response to hormones (Probable). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF (Probable). Involved in early response to iron deficiency (PubMed:27137867).
Similarity
Belongs to the peptidase M67A family. CSN6 subfamily.
Mass
36.024 kDa
Sequence
MSAPSDPAVATHPQAGAAAAASSSSGLTFKLHPLVIVNVSDHHTRVKAQAACSGDGASSAAAGGQPPRVFGCVIGVQRGRTVEIFNSFELVLDPVSGTLDRAFLEKKQELYKKVFPDFYVLGWYSTGSDVRDTDMQIHKALMDINESPVYLLLNPAINLSQKDLPVTIYESELHVIDGSPQLIFVRANYTIETVEAERISVDHVAHLKPSDGGSAATQLAAHLTGIHSAIKMLNSRVRVIHQYLVSMQKGDMPLDNSLLRQVSSLVRRLPAMESEKFQDDFLMEYNDTLLMTYLAMFTNCSSTMNELVEKFNATYERSTARRGGRGAFM

Gene
csn6
Protein
COP9 signalosome complex subunit 6
Organism
Dictyostelium discoideum
Length
309 amino acids
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.
Similarity
Belongs to the peptidase M67A family. CSN6 subfamily.
Mass
35.107 kDa
Sequence
MTDTTTTTTTDANKLVLEKSANSSGLEVDLHPLVLINISDHFTRTKVQSNYQDNCRVIGVILGVQNGRNVEICNSFEMVYATVDKQLVLDIEYLRKKYEQLFPLYDLLGWYSTGSQVSKDDILLHKQISEHNESPLYLMLDTDSPKSKDLPVIIYESELHIVNDEPTTIFVKTPYKIQTGEAERIGVNHIAKVTPSGSEGSGLTSHLFTMHNAISMLNIRVKALSDYLQAVKEKRLPYEQNILRKASSLCNQLPTIDTHDFKKSYLQEYNDVLLVTYLASITKTSASLNDTIDKYLVSNEKQSKRRFYQ