Protein
COP9 signalosome complex subunit 1
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD-1) complex.
Similarity
Belongs to the CSN1 family.
Sequence
MDDRKLAFFTAIEDQGGVIVKGRTRFERLFHIGRSSVPLCVDALKAAVQEAKAGSDILRYQMAVNSLFQAAPNEPEALLDKAWMESKEKENRDTTAHLQAELQGYKNNLIKESIRMGNEDLGKHFEAIGDVEAAMDSFWKMRTEVSSTEQLVDLGKLLVRVAIERRDWKSIGNHLKPLNSVNDSDPKAKALKTYSKIANGIAALGQERYKEAAFCFVEASSGVPPEIYNQIASPNDVAIYGGLLALATMDRHELQANLLDNDSFREFLQREPHIRRAITQFVNGRYAACIEILESYRPDYLLDIYLQKHVPKLYADIRTKSIVQYLKPFSCVRLDTMQKAFNGPGPSIEDELFTMIKDGKLNARIDAINKSKALQTLENYEKQALDRIRRMNIMAADLEVKGSRKPGGMNDIPFSMTTDDTVSLA