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csn-1

Gene
csn-1
Protein
COP9 signalosome complex subunit 1
Organism
Caenorhabditis elegans
Length
601 amino acids
Function
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
Similarity
Belongs to the CSN1 family.
Mass
68.402 kDa
Sequence
MQNELLDDPMDTGAPAAEAAAADEPLPPAHGIDREVTPKPAGNPDLMQQSLDNPAIPMHLIEKRDDRRESCDDGYSLTVNESAIDIESLACSYDSNAFFLRARFIARHCPILRADAYISLINYLKEHTTDITHYVAFFNELESELARKEFKNRQLNFQIPLRDQKWIEENGATWQSTTDQLQAEYKRHKDEGVKESTRRAMEDLFQHYMMAGKIDEAIRLYSRGIRDYCTQLKHSINMWINWMEVAICANDWGKLDTVTNTAYRSLKDADDAEKNSQQSQQAPPQRGENAPYMVERDPNAPIQTLTNRQLIETALAKCLAAQVLLKLRNKRYSQVVETILQIKTECLQSKWFVTSSDLGIYGMLSAMATMSRADLKLQVSGNGTFRKLLESEPQLIELLGSYTSSRFGRCFEIMRSVKPRLLLDPFISRNVDELFEKIRQKCVLQYLQPYSTIKMATMAEAVGMSSAELQLSLLELIEQKHVSLKIDQNEGIVRILDERDENAILKRVNVTCDRATQKAKSLLWKTTLAGANIHSISDKETRPKRKNQKESAKFDRNFGGIDVDEDPRGIAGPSGLSDDFNIAYDQQPQQQVQYLEDLGDI

Gene
csn-1
Protein
COP9 signalosome complex subunit 1
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
425 amino acids
Function
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD-1) complex.
Similarity
Belongs to the CSN1 family.
Mass
47.829 kDa
Sequence
MDDRKLAFFTAIEDQGGVIVKGRTRFERLFHIGRSSVPLCVDALKAAVQEAKAGSDILRYQMAVNSLFQAAPNEPEALLDKAWMESKEKENRDTTAHLQAELQGYKNNLIKESIRMGNEDLGKHFEAIGDVEAAMDSFWKMRTEVSSTEQLVDLGKLLVRVAIERRDWKSIGNHLKPLNSVNDSDPKAKALKTYSKIANGIAALGQERYKEAAFCFVEASSGVPPEIYNQIASPNDVAIYGGLLALATMDRHELQANLLDNDSFREFLQREPHIRRAITQFVNGRYAACIEILESYRPDYLLDIYLQKHVPKLYADIRTKSIVQYLKPFSCVRLDTMQKAFNGPGPSIEDELFTMIKDGKLNARIDAINKSKALQTLENYEKQALDRIRRMNIMAADLEVKGSRKPGGMNDIPFSMTTDDTVSLA