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csdA

Gene
csdA
Protein
Cysteine desulfurase CsdA
Organism
Escherichia coli (strain K12)
Length
401 amino acids
Function
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine, and transiently retains the released sulfur atom on a cysteine residue, in the form of a persulfide. Can also desulfinate L-cysteine sulfinate, which is the best substrate of the enzyme. Functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. Seems to participate in Fe/S biogenesis by recruiting the SufBCD-SufE proteins. Transfers sulfur to CsdE that increases the cysteine desulfurase activity of CsdA. Can also transfer sulfur directly to TcdA/CsdL in vitro. Appears to support the function of TcdA in the generation of cyclic threonylcarbamoyladenosine at position 37 (ct(6)A37) in tRNAs that read codons beginning with adenine.
Similarity
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
Mass
43.234 kDa
Sequence
MNVFNPAQFRAQFPALQDAGVYLDSAATALKPEAVVEATQQFYSLSAGNVHRSQFAEAQRLTARYEAAREKVAQLLNAPDDKTIVWTRGTTESINMVAQCYARPRLQPGDEIIVSVAEHHANLVPWLMVAQQTGAKVVKLPLNAQRLPDVDLLPELITPRSRILALGQMSNVTGGCPDLARAITFAHSAGMVVMVDGAQGAVHFPADVQQLDIDFYAFSGHKLYGPTGIGVLYGKSELLEAMSPWLGGGKMVHEVSFDGFTTQSAPWKLEAGTPNVAGVIGLSAALEWLADYDINQAESWSRSLATLAEDALAKRPGFRSFRCQDSSLLAFDFAGVHHSDMVTLLAEYGIALRAGQHCAQPLLAELGVTGTLRASFAPYNTKSDVDALVNAVDRALELLVD

Gene
csdA
Protein
4-hydroxyphenylacetate decarboxylase activating enzyme
Organism
Clostridium scatologenes
Length
312 amino acids
Function
Activation of 4-hydroxyphenylacetate decarboxylase under anaerobic conditions by generation of an organic free radical.
Similarity
Belongs to the organic radical-activating enzymes family.
Mass
36.063 kDa
Sequence
MKEKGLIFDIQSFSVHDGPGCRTSVFFIGCPLQCKWCANPESWTKKKHIMVAENVCKWKNGCRSCINACSHDSIKFSEDGKLKISWDTCEKCETFDCVNMCPNNALKQCVKEYTVDELMTILKRDFNNWGSDGGVTFTGGDPLMHHEFLVEVLKKCYDSQIHKAIETSGYAKQEVFLEVLKYIDFAFIDVKNMDREKHKQGTGVYNDLILSNIEALKKSNWNGRLVLRQPTIAGYNDSDENAYKLIEFMNKNSLYEINLLKFHRLGETKWNQLGKEYEYSKYGDMTNEKMEHLQQLYLDNNIACYIGDNTPF