Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling.
Similarity
Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
Sequence
MTTMMTDSGTASDSGAGLVDSTRNDTTTTTTTTTTPGDNDADDDNTNGTTTGHHDNNETDNNSKSYSSTHHVPAIDNTSTTNANDNEDAAGFLDRDQSPLSSISSPLSEPDNFEFDTEPIPSILSPKSTTSDNHARDGETPELDEDGQPPAKRRRVRETTPHNHSRKPKPESPPWKKFEAEGPTTIITEDGRRKSGRVNPVLLGMKPSDKKVTRKAIQTSPVSNKSSASTSRKPAPASSSNSKHAPAKMPPPPPPPKAPARKSATTHETRPSASRSRRRSPSPRRPATPPKPAAVGTRRSTRQALAHSRASYDDGQLSPGASRATPRIKLKVRPPLTVIPLVHPNQANVRPKLGPTFEEYFARAHEIPVEEGGQHIPDEEPKYTDEMALQDAKVILRVEKEVEPGGLLAPDRCSAFEPEAEEEPPRQWAHLDHLTKAMTNFRKLMYREQQLHMQAAKRIAIACEAEWRRRNPQPKTAEEIELEEMEASKAKWRQVIRAFAGTWENVRVEVNRRRLVEWEAEEQRRVKAALNQAVNLSEQKLQQRQAQVDGDEITDEDEDEDDEDLASGMPSVMGDEKESDEHSDQGSDEMSDENDEDEDEDNMSSSEDDDKKSTASDEGLTQEELRAKYANLPTLGTTDETEETTKDVEMADAPAAMDGSVANDDDTSDESVDMDDDLGSSEESDDDEEEEEDDEEEEESDDEPAGLLGLFFGKSELKKLKEEAVTEEPSVEPAGDVEMTDASAALRPELQVNGHAHEAPITNGTHTNEQLASSQTEGADDEVSLLVIPNDEIAAENTQTAAEPGSGVVEKDFLTNDSSLKYPNEIVQSENQTLPAKESVEAGGDLPMVDAPSTDDLQRETAAAPSLEAPPNTRHDSQETVAATDMQSQSQTQSPKTTDTKPTDVDTPHSELAVSVQKPDSRQSSPQPTTPTVKTEIPFLLRGTLREYQHHGLDWLAGLYANNTNGILADEMGLGKTIQTIALLAHLACHHEVWGPHLVIVPTSVMLNWEMEFKKWCPGFKILTYYGNQEERKRKRQGWNNDDVWNVCITSYQMVLQDQQVFRRRRWHYMILDEAHNIKNFKSQRWQTLLGFNTQARLLLTGTPLQNNLTELWSLLYFLAPPENGEGGFVDLTEFHNWFARPESQILESGREQLDDEARAIIAKLHKVLRPYLLRRLKADVEKQMPAKYEHVEFCRLSKRQRELYDGFLSRADTRETLQSGNYMSIINCLMQLRKVCNHPDLFVDRPIMTSFRMSRSVPADYEWKEKFIRNRLLATKPMTTVNLSFLNMIPTEYEDLSKTHTDRIAQLSSHRILLDLREAQKVRANNAYTALDPSSVKSNLVYLESAARWGRFEELQHCVYINALRRQQRPIYGKRLTEFLTLDTHLRPYKPRPRVPAKIMSWFEEDSFLLHNAIPTLQQRAESMEMTITKFACVTPAVVTGPEMNRFLLGERGIQLFEDLDLKLSAPVKYAPYMPPQPPPDPWHEARMRLTIQFPDKRLLQYDCGKLQALDKLLRKLQAGGHRALIFTQMTKVLDILEQFLNIHGHKYLRLDGATKVEQRQILTDRFNHDPRILCFILSTRSGGLGINLTGADTVIFYDQDWNPAMDKQCQDRCHRIGQTRDVHIYRLVSEHTIEANILRKASQKQMLDDVVIQEGEFTTDYFNRLSVRDVLGSNGEVIASNEDDVAANLAMDRVLGGPSTTGAGGYDGTADGGGGASQPPVRNVGRVLEMAEDREDVDAAKAAEKEIMQDEADFGEAGSTRPGTPGDGLADLDGQLLGGEENKEVEDEVIEYNAWGERMHTIDEYMLGFMAKALEGTPLELPRDRKKGRDRNRNRKGKDSRKR