Protein
Calpain-like protease palB/cpr-8
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Function
Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH.
Similarity
Belongs to the peptidase C2 family. PalB/RIM13 subfamily.
Sequence
MEARALEHERRLAESHGQEALKHAIAAAEIYMRAAEKAANPKDRNRLQRKCSDLIALGERLKANAKSAATSARSPVPESTRTLTIAEKTLLLKSSKLHGNIFPPWEKTPASDEFAASKAADGCFTDHSPFTLSPEQQDIFAGWKRPHEIFMDVPERGVDVFMTATESIDLGQDLATDCSVVASLCAAVRQFGPRTGSLLSSLMYPYDDDVKRPAVSQNGKYIFRMYFNGCWRKVLIDDRLPTSSSERTLYVVDRRNPYLIWPALIEKAYLKIRGGYDFPGSNSGTDLHALTGWIPEQIFLQTDDIELNETWSRIKTAYEQGNALVTLGTGKFSREEERTLGLVREHDYAVLDLRNDGNNRLFLVKNPWRDSLVWTGVGSTATSSTDRSGSPEESMSNTFWMTFEDVLQHFDSLYVNWSPSLFRFRQDHHFTWTIPPKAEELVFTQNPQYSILSHTGSPVWILLNRHWQDSELDILRERKQEHDFHQPLKSLGYMSLSLFASHPPGTRIPLSEGSHHALHQGPFVDSPNTLLRYSPTPGVAQTLVIAQSDLPLPSYSFTLSFFSNSPLTISPASDPLPYNETITGAWTRRTAGGSTVYPSYVTNPQYALTLTRPSPLSLVLSTERADNLPVHIAVLYSNGGQRVTAVVGRDLICSSAEYQRGCTFASTLPSSNTSNVTSSVASNNHGHTSSSLIDPGTYTIVLSTYEPGQTGRYSLRVSAACPFTIEPILSDAAGRLRTPAPSPATFRQGEGRVRARVDVARLTRASVLARSVKTGSTTQKTAMVRVALELGTIEGRKRVLASTASGGGGELAASLSNLSLSERLGGIGGIGGGHIHGGQGTTEGDGYSAKGEFADASLGLRTREVDLDPDVIRVYGGLWLVVEQIGGGGQGHVTEGSDDDGGGGGGGGGGVHVEISSDGVVSIGEWEVADED