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cpeb1-b

Gene
cpeb1-b
Protein
Cytoplasmic polyadenylation element-binding protein 1-B
Organism
Xenopus laevis
Length
568 amino acids
Function
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation and early development. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In the absence of phosphorylation and in association with tacc3/maskin, also acts as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Requires zinc for RNA binding. Involved in the cell cycle progression from S phase into M phase (By similarity).
Similarity
Belongs to the RRM CPEB family.
Mass
62.632 kDa
Sequence
MAFPLKDDLGRAKDCWGCSSDTPALSTCSNADIFRRINAMLDNSLDFTGVCTTPNTKGKCEHLQDYPDTEGAAASRMLFSTSHEPLPRGLPDTNDLCLGLQSLSLTGWDRPWSTQDSEAGGQSSTPTAAQSVFSMLNSPMGKPSPLGFLPLDPIGSDLVEKYPTHLLRSSRFDSRSILDSRSSSPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLPLGSGISRDPLRLGVGSRLDQDHAALAAATASPLGITKRWPGTSVWPSWDLLDSADDPFSIEREARLHRQAAAVNEATCTWSGQLPPRNYKNPVYSCKVFLGGVPWDITETGLINTFRVFGALSVEWPGKDGKHPRCPPKGNMPKGYVYLVFESEKSVRALLQACTQDLLSQDGLSEHYFKMSSRRMRCKEVQVIPWVLADSNFVRSPSQRLDPSKTVFVGALHGMLNAEALASIMNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLKAVSAAFVEIKTAKFTKKVQIDPYLEDSVCQVCNAQPGPFFCRDQVCFKYFCRSCWHWQHSMEILRHHRPLMRNQKSRDSS