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cort

Gene
cort
Protein
Protein cortex
Organism
Drosophila melanogaster
Length
483 amino acids
Function
Female meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C) (PubMed:17251266, PubMed:18020708). Required for the completion of meiosis in oocytes (PubMed:11252055, PubMed:10683177, PubMed:10924478, PubMed:17251266, PubMed:18020708). Activates the ubiquitin ligase activity and substrate specificity of APC/C and triggers the sequential degradation of mitotic cyclins in meiosis (PubMed:17251266, PubMed:18020708). Promotes the ubiquitination and degradation of CycA early in meiosis I and the degradation of CycB and CycB3 after egg activation (PubMed:18020708). Promotes degradation of mtrm at the oocyte-to-embryo transition (PubMed:24019759).
Similarity
Belongs to the WD repeat CORT family.
Mass
55.575 kDa
Sequence
MFVEMSVCDSPNKNSKLDKKSLTPFKKVRRKNWKQEAAYKSDTSKGQEVSYVGERFIPNRFERENIEFNLKYIGKRKERDILETGVTLTASYWRQSGFISNINRTFGIGERRLFQFSSQQGTRSRVVDNDSADSDWPCNPRARPYAIQNATHEMPGICSPVDYNMMDWSSGGMVAMSSGQDVMLWRNLDESTMVFSVESPTSLKYSPDGKHLAIGCMDRNYPVLDLWEVRSPTEFLVSYRKLFFKSMGYISCIEWSHDGKEVICGTQCGVIIVLAMPTLNTLMQLREHRHTVKKMKFAPTHKYFASSDTDGKIFIFDAVLKVRLLKLDGRSIVFDWHPWTGEDLAVAERSPASIFIFNIPRRQFVASYRRRDDRIVIKTLTYSKITGELLVNVIRRDDADLAVCEILVLASLNRVVDLMSHQDRGTLFLMWNPDGTKIATGGLDDTFSLWNFFPTYKREAILRKQEQKAKDKCSSLSLYKGIR

Gene
cort
Protein
Protein cortex
Organism
Heliconius erato
Length
449 amino acids
Function
Controls wing pigmentation patterning by regulating scale cell development, thereby playing a key role in mimicry and crypsis (PubMed:27251285). Probably acts as an activator of the anaphase promoting complex/cyclosome (APC/C) that promotes the ubiquitin ligase activity and substrate specificity of the APC/C (By similarity).
Similarity
Belongs to the WD repeat CORT family.
Mass
51.448 kDa
Sequence
MDRTTFGRKTFNTQRNRLDRFVAPRDSFSETRRRRSWHAACDVQPINNDIWFGKNLKKKKYTKYLDKALDLESPDKSNSIKRMVQPWPCIPRKKTYLSSADSILDLPTYSYAIFPELLDWSNDNVLVAALGRNYHKWSWRSQSLISQGYAEYQIQCCKFDPRGELLLLGTYMKTVEIHNNVKSKKIDSNTCNCLEKDNRNCSITAVDWSPTGNSFATGCSWGAVTSFTRAAKLISWRHFVREAILLILIALSPNARYLAVTAVNTALVLLLTWPSLEMYSSIDSDWTIRTISWHPWRSALLGVGAVTDDLQARIALWDAPTCKVRDTSIGPKRYRLDAMLFSHRTGELVLSMWNSDRAILHPKACSQLVVMSDPDTMVDQWGEGRSGLDRVRTMVFSPDGTKLATATSDEDLIIWNFLPEDKKMKKTKCRFFSALPEYLDEAMQGYSLR

Gene
cort
Protein
Protein cortex
Organism
Heliconius melpomene
Length
447 amino acids
Function
Controls wing pigmentation patterning by regulating scale cell development, thereby playing a key role in mimicry and crypsis (PubMed:27251285). Probably acts as an activator of the anaphase promoting complex/cyclosome (APC/C) that promotes the ubiquitin ligase activity and substrate specificity of the APC/C (By similarity).
Similarity
Belongs to the WD repeat CORT family.
Mass
51.096 kDa
Sequence
MDRRTFDRKTNNPQRYRLDRFVATRDSFSETRRRRSWHAAFDVHPVNNDRWSEGNLKKKNYIKYLDKAFDLESPDKNKSIKRMNRLWPCIPRKKTYLSSADSILDLPTYSYAIYPELLDWSNDNMLVAALGSSYHKWSWRSQSLIGHGFAEYEIQCCKFDPRGELLALGTYMKTLEIHNNSKSKKIMSNTCKCLEIDNMNCSITAVDWSPTGNSFAAGCSGGAVTSFTRAAKLISWRHLVREAILLIRVSPNARYLAVTAMNTALVLLLSWPSLEMYSSIDSDWSIRAICWHPWRSALLGVGAVTDDLQARIALWNAPTREVRDTSIGPKGYRLDSMLFSHRTGELVLSMWHSDRATLHPKTCSQLVVLSDPDTMVDQWGEGRSGLDRVRTMIFSPDGTKLATATTDEDLIIWNFLPEDNKMKKTKCRSFSALPECLDNAMLGYSLR

Gene
cort
Protein
Protein cortex
Organism
Biston betularia
Length
441 amino acids
Function
Controls wing pigmentation patterning, possibly by regulating scale cell development (PubMed:27251284). Probably acts as an activator of the anaphase promoting complex/cyclosome (APC/C) that promotes the ubiquitin ligase activity and substrate specificity of the APC/C (By similarity).
Similarity
Belongs to the WD repeat CORT family.
Mass
50.902 kDa
Sequence
MGVGSSLRMQLTAQKPRVDRFVVPRYSLPEIHRRMTWSDRCEKYNGEIWSSKYLQQKRYINFLDEAFGLAPLKAQQRNSDTFDDWCWPCAPRKKSYLSTADNVLDLPSYSITSFPDVLDWSHDDILVAALGKKYHKWSWRTQSPVDQGQTMFDIRCCKFDPKGKRLLLGTDMRVEVHNELSKCQFVQYCKCNIQICTITAIDWSPTGNSFVTGCSRGRICAMNEKDFPIKSLVLIEGAMLVVKISPNARYVAVAGVHKHRVWILSWPDLIRFRFMKTNEIVKDLNWHPWQTALLGVATLSSDRHASMIIWEPHATDKLRQQDVGRGRYSIDAMRFNNKTGELLLSLWSLDVNVPYPKSSELVVMSNFDTVVDHWGESHTGLNRIRTMVFSPDGTKLATATADEDLIIWNFLPNDYKKILARKKFTAFPQFLDICSYGYTIR

Gene
Cort
Protein
Cortistatin
Organism
Rattus norvegicus
Length
112 amino acids
Function
Neuropeptide with neuronal depressant and sleep-modulating properties.
Similarity
Belongs to the somatostatin family.
Mass
12.201 kDa
Sequence
MGGCSTRGKRPSALSLLLLLLLSGIAASALPLESGPTGQDSVQDATGGRRTGLLTFLAWWHEWASQDSSSTAFEGGTPELSKRQERPPLQQPPHRDKKPCKNFFWKTFSSCK

Gene
Cort
Protein
Cortistatin
Organism
Mus musculus
Length
109 amino acids
Similarity
Belongs to the somatostatin family.
Mass
11.613 kDa
Sequence
MMGGRGTGGKWPSAFGLLLLWGVAASALPLESGPTGQDSVQEATEGRSGLLTFLAWWHEWASQASSSTPVGGGTPGLSKSQERPPPQQPPHLDKKPCKNFFWKTFSSCK

Gene
CORT
Protein
Cortistatin
Organism
Homo sapiens
Length
105 amino acids
Function
Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.
Similarity
Belongs to the somatostatin family.
Mass
11.532 kDa
Sequence
MPLSPGLLLLLLSGATATAALPLEGGPTGRDSEHMQEAAGIRKSSLLTFLAWWFEWTSQASAGPLIGEEAREVARRQEGAPPQQSARRDRMPCRNFFWKTFSSCK