Protein
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
Organism
Caenorhabditis elegans
Function
FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
Similarity
Belongs to the UbiH/COQ6 family.
Sequence
MKLPGGTIICARNASSYYDTVIVGGGMVGNAMACSLGANKSFQSKSVLLLDAGRSPSLASFKPGAPFNNRVVATSPTSIDTFKKLGVWDQINSHRTKKVNRLFVFDSCSTSEIEFERGQQEEVAFIIENDLIVGSLYEKLAEYKNVDVKTGAKVEDCSIPNALENMATIKLENGDVIETSLLIGADGVNSKVRHASNLDYTTFNYNQHGLVAIVNIETANGKNETAWQRFTTLGPVALLPLSDTVSGLTWSTSPEEAQRLKQLPSDQFVDELNSALFSQNNQIPLVNQTIFALNRMNPFRTETFGRKAEGTTPPHVITVQDKSRASFPLGFGNAHSYITTRCALIGDAAHRMHPLAGQGVNLGWSDVQILDKVLGDAVREGADIGSITYLREYDSAAQKHNLPVMVSVDLLNRLYRTDAPAIVAARAFGLNAFNSLGPVKNFLMNYLSAHR