Protein
Transcriptional repressor CopY
Organism
Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
Function
Acts as a copper responsive repressor. Binds to DNA in complex with Zn(2+), repressing the transcription of the copYZAB operon. Exchange of the bound zinc by two copper ions delivered by CopZ Cu(1+)-bound form causes release of CopY from the promoter, leading to the transcription of the operon.
Similarity
Belongs to the BlaI transcriptional regulatory family.
Sequence
MEEKRVLIKISDSEWEVMRVIWTLGQANAQQITQILADSMDWKVATVKTLLGRLVKKEALWTEQEGKKFIYHPAVSEMENVRSATENLFSHICAKRVGATIADLVEEATLTQEDIQQIMKQLNKKEPVETIECNCIPGQCECKKQ