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comDE

Gene
comDE
Protein
Sulfopyruvate decarboxylase
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Length
387 amino acids
Function
Involved in the biosynthesis of the coenzyme M (2-mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde. Is not able to decarboxylate the analogous compounds 2-oxoglutarate or 2-oxosuberate.
Similarity
Belongs to the TPP enzyme family.
Mass
42.301 kDa
Sequence
MYVVNPEEKVIEIMKQTGIDLAATLPCDRIKNLLPLVSENFPEIKLTREENGVGICAGIYLAGGKPMMLIQSTGLGNMINALESLNVTCKIPLPILASWRGVYKEGIEAQVPLGAHLPSILEGAGLTYTIIGETEKLPLLENVILDAFENSRPHIALVSPKVWEASECCAWQAAGMPIKPEIMERTCRFSLTSGTLKPFMLRNDAICTLASELDDEITVTNLGVPCKELYACRDRELNFYMFGSMGLVSSIGLGLALRSEKTVITFDGDGSLLMNPNALLEIAKEAPKNLIIIALDNGAYGSTGSQETCALRYIDLEIFANACGIQNTAKVNSKEGVIEAFRKFKAMRELSFIHVILKPGNTNAPNIPMSPEEATKRFKETLDVKKF