cofE

Coenzyme F420:L-glutamate ligase

257 amino acids

Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.

Belongs to the CofE family.

27.6 kDa

MEVFAVEGVPEVRPGDDVAELLVEQADLQDDDVVCVASTIVSKANGRGRSLSSYEPSGRAERIAATIEDIADEEKDPRMAQAILDECEEVLVEAPFILGVTKFGHITVNAGIDRSNVPGADLLLLPEDPTAEAEAIRDGIREHAGVEPSVIVTDTSGRPFRLGQRGVALGWAGLSASRDWRGEHDRDGRELEATVQAVVDELAAAANLVTGEGDGGTPAAVVRDFDFGDHAGSEQLFRDPEKDVVRQALREWSHVRD

cofE

Coenzyme F420:L-glutamate ligase

255 amino acids

Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.

Belongs to the CofE family.

27.853 kDa

MKFEAIAVENIPLIHTGDDLPSIICKNLELQDRDIVIVASTIVAKAEGKVFRLEDITPGKVALEMASRNGKDARFIQAVLSLSREVLVEKPFMLVTTLAGHTCVNAGIDESNIEDGFLLYPPENSDASASRLGQELETLSGKKLSVIVTDTNGRAFKIGQTGAAIGIYKIKPVKHWIGEKDLFGKVLEVAEEAIADELAGAANLLMGEGAGGTPVVVIRGFDYYCEEETFIKEMYRPEEMDVIKKGLRCLQKRVE

cofE

Coenzyme F420:L-glutamate ligase

254 amino acids

Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.

Belongs to the CofE family.

27.899 kDa

MKFEAIAVEKIPLIRKGDDLPYIICERIELQDRDIIVIASTIVAKAEGETFRLEDITPGEEALAIASRTGKDARFIQAVLSRSREVFVEAPFMLVTTLAGHTCVNAGVDESNIEHGFLLYPPKNPDSSASKLGERLESISGKKLSVIITDTNGRAFKIGQTGVAIGIYKIKPIKRWIGEKDLFDKVLEITEEAVADELAGAANLLMGEGAGGIPVAVIRGLDYYCEEEISMSENYRPEDMDVIKKGLRCLQKKN

cofE

Coenzyme F420:L-glutamate ligase

254 amino acids

Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.

Belongs to the CofE family.

27.741 kDa

MKFEAIAVEKIPLIHEGDNLPSIICEKIGLQDRDIMIIASTIVAKAEGEIFRLEDITPGEEALEIAARTGKDPRFIQAVLSKSREVFVETPFMLVTTLAGHTCVNAGIDESNIENGFLLYPPENPDASALKIGKELEKLSGKKLSIIITDTNGRAFKIGQTGVAIGIYNIKPVKRWIGEKDLFGKVLEITEQAIADELAGAANLLMGEGAGGIPVVIIRGLDYYCEGDTSIKESYRPENMDVIKQGLRCLRNKK

cofE

Coenzyme F420:L-glutamate ligase

253 amino acids

Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.

Belongs to the CofE family.

26.441 kDa

MHAFAVDGLPEIDAGDDLAALVAERADLTDGDVVCVASTVVSKAEGRTAALAEFTPGPRAEEIAARLADVTGEQKDPRFAQAVIEEATEVIMDAPFLLTETTCGHVGVNAGIDRSNTGGAELLLLPKRPAESAARIQAGLAADVGVVVTDTSGRPFRHGQRGVALGWAGLPAARDWRGETDRDGHELAVTVEAVVDELAATANLVSGEGDDGTPVVVVREFEFGDHDGSEQLFRAVDGDFVRQALRGWTFDGA

cofE

Coenzyme F420:L-glutamate ligase

253 amino acids

Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.

Belongs to the CofE family.

26.441 kDa

MHAFAVDGLPEIDAGDDLAALVAERADLTDGDVVCVASTVVSKAEGRTAALAEFTPGPRAEEIAARLADVTGEQKDPRFAQAVIEEATEVIMDAPFLLTETTCGHVGVNAGIDRSNTGGAELLLLPKRPAESAARIQAGLAADVGVVVTDTSGRPFRHGQRGVALGWAGLPAARDWRGETDRDGHELAVTVEAVVDELAATANLVSGEGDDGTPVVVVREFEFGDHDGSEQLFRAVDGDFVRQALRGWTFDGA

cofE

Coenzyme F420:L-glutamate ligase

253 amino acids

Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.

Belongs to the CofE family.

27.293 kDa

MEALAVDGLPEIHEGDDLAALLEDRVDFADGDVLCVASTIVSKAEGRAFDRESFPPSDRAKAIADRLSTITGEQKDPRFAQAVLEESEELLTESPFLLSVTRFGHITVNAGIDRSNVPGADLLLLPEDPTASAERLSSALGVPVVVTDTSGRPFRYGQRGVAVGWAGLPAARDWRGETDRDGRELGVTVQAVVDELAATANLVAGEGDDGTPAVVVREWSFGDHDGSDLLFRREEDDIVREALRQWTFDGHQQ

cofE

Coenzyme F420:L-glutamate ligase

252 amino acids

Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.

Belongs to the CofE family.

27.135 kDa

MGGLPTLRIEPVPLERKVRPGDDLAELIAESAELEEGDVLAIAHTVVSKAEGALISLDEIEPSPFAKTLAERTGKDPRVVEVILREAESIVRVGPDFIITEVRGGMVCANAGVDESNAPPGYVIVLPEDPDRSARELRRRLRELVGVDVGVIITDTQGRPFREGVVGVAIGASGVPVLADRRGDRDLYGRELKITIVALGDLLASAAELVMGQADEGTPAVIFRGLKPELERFEGPRKARAIIRSPSRDIFR

cofE

Coenzyme F420:L-glutamate ligase

252 amino acids

Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.

Belongs to the CofE family.

26.538 kDa

MGISLIGVEGMPLVGAGDDIAYLIISALNEGGEDLLDGDIIVIAETIVSKAEGNIISLEEIKPSPEALDIAERTGKDPSLVEAILGESSEIIRVGHDFIVSETRHGFVCANAGIDESNVDDGLATPLPRDPDGSAEKILRTLQEATGRELAVIISDTQGRPFREGAVGVAVGVAGLSPIWDRKGERDLYGRSLETTRVAVADELAAAASLVMGQADEGVPAVIIRGYPWGHLRSDGGVKPLLRPRELDVFRG

cofE

Coenzyme F420:L-glutamate ligase

251 amino acids

Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.

Belongs to the CofE family.

27.294 kDa

MELFAVPGLPEIRDGDDLAAMIDERVDLREGDVVVVASTVVSKAEGRTFDLSDFPASERAEAVADRLAEIAGEEKDPRFAQAVIEESTELIMEAPFLLTATRFGHIGVNAGIDQSNVPDGDLLLLPERPSESAARIREGIAADRVVVSDTCGRPFRHGQRGVAIGWAGLPASRDWRGERDRDGREMGVTVQNVIDELASAANLVAGEGDGGTPVVVVRDWEFGDHDGSDNHFREVEGDFVRQALRQWTFDD

cofE

Coenzyme F420:L-glutamate ligase

249 amino acids

Catalyzes the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. May be able to add up to four gamma-linked glutamates, since F420-4 is a species that was isolated from A.fulgidus.

Belongs to the CofE family.

27.261 kDa

MRVEVFPVEGLPLIKEGDDLAELISSRVRFEDGDVLVVCSTVISKAEGRIRRLEEFNPSERAKEIAARIGKPAEFVQAVLEESEEVLLDFPFLLVKAKFGNVCVNAGIDASNVEEGSLLLPPLDPDGSAEKLRRRILELTGKRVGVIITDTNGRCFRRGVVGFAIGISGVKAMKDWIGRKDLYGRELEVTVECVADEIAAFANLLMGEGGDGIPAVVVRGLNVAGEGSMEEIYRSEEEDVIRRCLKRCL

cofE

Coenzyme F420:L-glutamate ligase

249 amino acids

Catalyzes the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. Cannot use F420-2 as substrate to add more glutamates. Exhibits maximum activity with GTP, compared with UTP (66%) and dGTP (25%); with ATP, only F420-1 is observed as the product; CTP and TTP support no activity.

Belongs to the CofE family.

27.148 kDa

MIKEKRKVEVIGLELPIFKGGEQINLSELIAQYPIEDGDIIVIAETLISKLEGGVIDRDKIIPSKEAIELAKKTGKDPKVVQVILDEAKEIVKVGKNFIITETKHGFVCANSGVDESNIYKGIKILPKNPDESAEKIRKEIEKLTGKRVGVIISDSVGRPFRKGAVGIAIGVSGILALWDRKGEKDLFGRELKTTEVAIADELASMANVVMGEADEGIPVVIIRGANVPFGNGKGRDLIRPKEEDVFRN

cofE

Coenzyme F420:L-glutamate ligase

248 amino acids

Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.

Belongs to the CofE family.

27.042 kDa

MIKERVKMEVIGLEIPLISGNEEYTLAELISKYPLEENDIIVIAETVVSKSEKNVILKDTIKPSNEAIELSKKLGKEPEVVQVILDESNETVRLGPNFIVTETKHGFVCANSGVDESNTSKGIKPLPKNPDKSANEIRKGIEEITGKKVGVIINDSMGRPFRKGSCGVAIGVSGVCGLWDRKGEKDLFGRELKTTEVGIADELAATASVVMGQSDEGIPLVIIRNAPVPFKEGTGKELIRKKEEDVFR

cofE

Coenzyme F420:L-glutamate ligase

248 amino acids

Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.

Belongs to the CofE family.

26.957 kDa

MITERVKMEVIGLEIPLISGNEDYTLAELISKYPLKDKDIIVIAETVVSKSEKNVILKDTIKPSNEAIELSKKLGKEPEVVQVILDESNETVRLGPNFIVTETKHGFVCANSGVDESNTSKGIKPLPKNPDKSANEIRKGIEEITGKNVGVIINDSMGRPFRKGSCGVAIGVSGVCGLWDRKGEKDLFGRELKTTEVGIADELAATASVVMGQSNEGIPLVIIRNAPVPFNDGTGKELIRKKEEDVFR

cofE

Coenzyme F420:L-glutamate ligase

248 amino acids

Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.

Belongs to the CofE family.

26.989 kDa

MIKERVKMEVIGLEIPLISGNEDYTLAELISTYPLEDKDVIVIAETVVSKIEKNVILKNEITPSNEAMELSKKLGKEPEVVQVILDESNEIVKLGPNFIITETKHGFVCANSGVDESNTSKGIKPLPKNPDKSAEEIRMGIEKITGKKVGVIINDSMGRPFRKGSCGIAIGVSGVCGLWDRKGEKDLFGRELKTTEVGIADELAATASAVMGQSNEGIPLVIIRNAPVPFTNGTGKELIRKKEEDVFR

cofE

Cofilin-4

135 amino acids

Controls actin polymerization and depolymerization.

Belongs to the actin-binding proteins ADF family.

15.659 kDa

MNSCASINDEVITKYNELILGHISKGIIIKFSDDFKEVVFEDSFNGESFEDYINKFPQDDCRYGVYDFSYMDNKENKKNKIFFISWCPVETKIKNKIVHTATEQSIYKKLVGIDAIIKATDNTEISQSLVEERCK