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cobB1

Gene
cobB1
Protein
NAD-dependent protein deacetylase 1
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Length
299 amino acids
Function
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
Similarity
Belongs to the sirtuin family. Class II subfamily.
Mass
31.559 kDa
Sequence
MRMRPTLSWTPGADLPPGTTDLAPVADALRAGGVLVLSGAGISTESGIPDYRGEGGSLSRHTPMTYQDFTAHPEARRRYWARSHLGWRTFGRARPNAGHRSVAAFGRHGLLTGVITQNVDGLHQAAGSEGVVELHGSLDRVVCLSCGVLSPRRELARRLEEANAGFSPVAAGINPDGDADLTDEQVGDFRVVPCAVCGGVLKPDVVFFGENVPPRRVEHCRELVRGASSLLVLGSSLTVMSGLRFVRQAAEAGKPVLIVNRDATRGDRLAVTRVALPLGPALTTVADRLGLRVGDAATA

Gene
cobB1
Protein
NAD-dependent protein deacetylase 1
Organism
Mycobacterium avium (strain 104)
Length
282 amino acids
Function
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
Similarity
Belongs to the sirtuin family. Class II subfamily.
Mass
29.899 kDa
Sequence
MTVGRAESPELVAVLAGRRIAVLTGAGISTDSGIPDYRGPESPPSNPMTIRQFTGDPAFRQRYWARNHVGWRHMDDTLPNAGHRALAALEDAAVVTGVITQNVDLLHTKAGSRNVIDLHGSYARVICLGCGDTTSRAALAERLEALNPGFIERTEAIGGLAVAPDADAVVAETASFRYVDCARCAGMLKPDIVYFGESVPKDVVAAAYRLIDESDTLLVAGSSLTVFSGYRFVRHAAARGIPIAIVNRGDTRGDHLATVKVDGGCSELLALLADELSPLPTH

Gene
cobB1
Protein
NAD-dependent protein deacetylase 1
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Length
281 amino acids
Function
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
Similarity
Belongs to the sirtuin family. Class II subfamily.
Mass
30.298 kDa
Sequence
MEEGAALEGVVKLLEAGSVLAVTGAGVSTDSGIPDYRSPRGSLNQGRPMTYQEFRFDPVASHRYWARSFVGWRVMADAQPNRTHYALVELERAGLLSGIVTQNVDGLHRRAGSENLVALHGDLATIVCLQCGHREARELLDARLDHLNPGYFDSIALDPSAVNPDGDVTLDDHHVQRFTMAGCARCGSVLLKPDVVYFGEPVPSIRKTRVAQLLDGADAVVVAGSSLAVMSGYRIVIEAQRAGKPVAVINGGPGRADHRVDILWRTRVGPAFDQILDALDL

Gene
cobB1
Protein
NAD-dependent protein deacetylase 1
Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Length
254 amino acids
Function
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
Similarity
Belongs to the sirtuin family. Class U subfamily.
Mass
27.89 kDa
Sequence
MRLIASDLRSGVERLGDMIAEAKTIVPFTGAGISTECGIPDFRSPGGIWTRNRPIPFDGFVASQEARDESWRRRFAMEETFAAARPGRGHRALASLYRAGKVPAVITQNIDNLHQASGFAHEHVIELHGNTTYARCVGCGQTYQLDWVKRRFDQDGAPNCTVCDEPVKTATISFGQMMPEEEMQRATALSRACDLFIAIGSSLVVWPAAGFPMMAKRAGARLVIINREPTEQDDIADLVIRHDIGETLGPFVGN

Gene
cobB1
Protein
NAD-dependent protein deacetylase 1
Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Length
254 amino acids
Function
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.
Similarity
Belongs to the sirtuin family. Class U subfamily.
Mass
28.086 kDa
Sequence
MAVDFTTDELDEVASLIARSSCNVALTGAGVSTASGIPDFRGPQGVWRRVDPEKFEISYFYNNPDEVWDLFVKYLLPAFNVKPNPAHYALAEMERLGKLCAVITQNVDRLHQAAGSKNVIELHGALEYAVCTNCGSKYALAEALKWRKSGAPRCPKCGGVIKPDVVFFGEPLPQDALREAFMLAEMAEVFMAIGTSLAVYPANQLPLVAKKRGAKLVIINADETYYDFFADYIIRGRAEEVLPKLLDRLRGMLF

Gene
cobB1
Protein
NAD-dependent protein deacylase 1
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
250 amino acids
Function
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.
Similarity
Belongs to the sirtuin family. Class III subfamily.
Mass
26.655 kDa
Sequence
MRAVVELLAGARRLVIFTGAGVSAESGIPTFRDALGGLWARYDPAALATPAAFADDPALVWGWYEWRRLKVLGVQPNPAHRAIAALSGRIANTRLVTQNVDDLHERAGSRDVLHLHGSLHAPRCATCAAAYRDALPDSVEPEEGRRIEPPRCPACGGQVRPGVVWFGEALPEAALREAFAAACECDLLLSVGTSGVVQPAARIPGLALEHGASVVHVNPQPVRTRHPREHCLVGPAGEVLPELLRRAFPG

Gene
cobB1
Protein
NAD-dependent protein deacylase 1
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Length
245 amino acids
Function
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.
Similarity
Belongs to the sirtuin family. Class III subfamily.
Mass
27.143 kDa
Sequence
MDEKLLKTIAESKYLVALTGAGVSAESGIPTFRGKDGLWNRYRPEELANPQAFAKDPEKVWKWYAWRMEKVFNAQPNKAHQAFAELERLGVLKCLITQNVDDLHERAGSRNVIHLHGSLRVVRCTSCNNSFEVESAPKIPPLPKCDKCGSLLRPGVVWFGEMLPPDVLDRAMREVERADVIIVAGTSAVVQPAASLPLIVKQRGGAIIEINPDETPLTPIADYSLRGKAGEVMDELVRHVRKALS

Gene
cobB1
Protein
NAD-dependent protein deacylase 1
Organism
Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)
Length
242 amino acids
Function
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.
Similarity
Belongs to the sirtuin family. Class III subfamily.
Mass
27.403 kDa
Sequence
MDFKILKEKLPQSNLTVVLTGAGISKESGIPTFRGEDGLWKKYNPEELATPWAFQRNPALVWEWYDYRRRIISKAKPNKCHLLIAEFEERFKNVRVITQNVDGLHEAAGSTNVIELHGNIWKVKCTKCDFRGINREVPLSKIPPECPKCGSIVRPDVVWFGEPLPSDKLTEAMELSQRADLFIVIGTSLMVQPAASLPFLALERGAFVVEVSPEETPLSRKAHLFFQMGAVEFAMKFEEKEG

Gene
cobB1
Protein
NAD-dependent protein deacetylase 1
Organism
Geobacillus kaustophilus (strain HTA426)
Length
242 amino acids
Function
NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.
Similarity
Belongs to the sirtuin family. Class U subfamily.
Mass
27.044 kDa
Sequence
MTITSWLAASRHTVVLTGAGMSTESGLPDFRSPRTGLWARFNPSELATIDALYHRRESFVEFYQYRIRTLQQCQPHDGHRLLADWERRGIVQTIVTQNVDGFHQEAGSRRVIELHGSLRTVHCQRCGESKPSFVYLHGVLTCECGGVLRPSVVLFGEPLPEKAITEAWEAAQQADLFLVLGSSLQVSPANQLPLVAKRNGAKLVIINWEPTELDDLADAVIHQRKIGEVLNELNEQLAEVDP

Gene
cobB1
Protein
NAD-dependent protein deacylase 1
Organism
Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Length
230 amino acids
Function
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.
Similarity
Belongs to the sirtuin family. Class III subfamily.
Mass
25.167 kDa
Sequence
MESGIPTYREKQTGFWACHNPERLETAKAFRENPSLVWGWYLWRRQQFSKAQPNAAHLALREMAGSMGTVSIITQNIDDLHERAGSVDVLHLHGSLSKPKCFACHRPGMVRNESAIMEEGALIEPPRCTRCNGKLRPGVVWYGEDLLPDVWKSALSLVKSCDVLISVGTSGIVTPAADLPNIALACGATVIHVNTVDVGMGAPNEIMLIGRATQILSHLSAFLSRELNSP