CNS1

Hsp70/Hsp90 co-chaperone CNS1

385 amino acids

Co-chaperone that binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). Stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. Involved in only a subset of Hsp90 functions.

Belongs to the TTC4 family.

44.112 kDa

MSSVNANGGYTKPQKYVPGPGDPELPPQLSEFKDKTSDEILKEMNRMPFFMTKLDETDGAGGENVELEALKALAYEGEPHEIAENFKKQGNELYKAKRFKDARELYSKGLAVECEDKSINESLYANRAACELELKNYRRCIEDCSKALTINPKNVKCYYRTSKAFFQLNKLEEAKSAATFANQRIDPENKSILNMLSVIDRKEQELKAKEEKQQREAQERENKKIMLESAMTLRNITNIKTHSPVELLNEGKIRLEDPMDFESQLIYPALIMYPTQDEFDFVGEVSELTTVQELVDLVLEGPQERFKKEGKENFTPKKVLVFMETKAGGLIKAGKKLTFHDILKKESPDVPLFDNALKIYIVPKVESEGWISKWDKQKALERRSV

cns1

Hsp70/Hsp90 co-chaperone cns1

358 amino acids

Co-chaperone that binds to the molecular chaperones Hsp90 and Hsp70. Stimulates Hsp70 ATPase activity, but not Hsp90 ATPase activity. Involved in only a subset of Hsp90 functions (By similarity).

Belongs to the TTC4 family.

40.531 kDa

MAGFQSSEVDPNTKNKNAEEMFNELNKVPFFMQSLEDVGDESENNVQLDALKALAYEGEPHEVAQNFREHGNECFASKRYKDAEEFYTKALAQKCGDKDIEIACYSNRAACNLLFENYRQVLNDCAQVLQRDSTHAKAYYRSAKALVALKRYDEAKECIRLCSLVHPNDPAILALSKELQKKSDDFEKRESEKKRVAQEKVIAAKTVLLALQERHIKTKTTEHPPDLGDAMISLSTFDDPKSELFFPTILLYPLVYQSDFVPSVSENCTPLELLKTVFQSPAPWDVHQLYNPDSLDVFATTDTLGLIKVGKNVPILKALTHPKVTLIDGLVQLHVVPHHLASDWISSWKKNKQENAKN