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cnb-1

Gene
cnb-1
Protein
Calcineurin subunit B
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
174 amino acids
Function
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
Similarity
Belongs to the calcineurin regulatory subunit family.
Mass
19.769 kDa
Sequence
MGNTTSSVLDNIVQGSNFDREEVDRLRKRFMKLDKDNSGTIEREEFLSLPQISTNPLATRMIAIFDEDGGGDVDFQEFVSGLSAFSSKGNKEQKLRFAFKVYDIDRDGYISNGELFIVLKMMVGSNLKDQQLQQIVDKTIMEADLDKDGKISFEEFTKMVENTDVSMSMTLDQF

Gene
cnb-1
Protein
Protein phosphatase 2B regulatory subunit cnb-1
Organism
Caenorhabditis elegans
Length
171 amino acids
Function
Regulatory subunit of tax-6/calcineurin A, a calcium-dependent, calmodulin-stimulated protein phosphatase (PubMed:12221132). Confers calcium sensitivity (PubMed:12221132). Plays a role in egg-laying, fertility, growth, movement and cuticle development (PubMed:12221132, PubMed:12684004). Plays a role in sensitivity to CO2 levels (PubMed:18524955). Regulates expression of tax-6 inhibitor rcn-1 (PubMed:12684004). Negatively regulates nicotinic acetylcholine receptor (nAChR) sensitivity to nicotine (PubMed:15990870). Negatively regulates lifespan (PubMed:19279398). Involved in endocytic processes including coelomocyte endocytosis, intestine apical endocytosis and synaptic vesicle recycling (PubMed:20803083, PubMed:21345307). May negatively regulate autophagy (PubMed:19279398).
Similarity
Belongs to the calcineurin regulatory subunit family.
Mass
19.672 kDa
Sequence
MGADASLPMEMCSNFDAYELRRLTRRFKKLDVDGSGSLSVEEFMSLPELQQNPLVQRVIDIFDEDGNGEVDFREFIQGISQFSVKGDKNTKLKFAFRIYDMDRDGFISNGELFQVLKMMVGNNLKDSQLQQIVDKTILFHDKDGDGKISFQEFCDVVEHTEVHKKMVLENI