CMR1

DNA damage-binding protein CMR1

522 amino acids

DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA in vitro (PubMed:22367945). May be involved in DNA-metabolic processes (PubMed:23349438).

Belongs to the WD repeat DDB2/WDR76 family.

59.156 kDa

MPELTEFQKKRLENIKRNNDLLKKLHLSGVASQIKHEAGVLEKSRAPAKKKQKTTNTRATKSASPTLPTRRSRRLRGESADDVKGIPNVNDNQLLKMGSPDGQDKNFIDAIKEKPVIGDVKLSDLIKDEDESALLEKFKRFNNGNFSSGDFFEEIKKRQGDVTGMDEFDLDLYDVFQPNEIKITYERISATYFHPAMEKKLIIAGDTSGTVGFWNVRDEPLADSEEDRMEEPDITRVKLFTKNVGRIDCFPADTSKILLTSYDGSIRSVHLNNLQSEEVLTLKNEYDDSLGISDCQFSYENPNVLFLTTLGGEFTTFDTRVKKSEYNLRRLADKKIGSMAINPMRPYEIATGSLDRTLKIWDTRNLVKKPEWSQYEDYPSHEIVSTYDSRLSVSAVSYSPTDGTLVCNGYDDTIRLFDVKSRDHLSAKLEPKLTIQHNCQTGRWTSILKARFKPNKNVFAIANMKRAIDIYNSEGQQLAHLPTATVPAVISWHPLRNWIAGGNSSGKIFLFTDDSGTIKQEE

CMR1

DNA damage-binding protein CMR1

522 amino acids

DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA in vitro (PubMed:22367945). May be involved in DNA-metabolic processes (PubMed:23349438).

Belongs to the WD repeat DDB2/WDR76 family.

59.156 kDa

MPELTEFQKKRLENIKRNNDLLKKLHLSGVASQIKHEAGVLEKSRAPAKKKQKTTNTRATKSASPTLPTRRSRRLRGESADDVKGIPNVNDNQLLKMGSPDGQDKNFIDAIKEKPVIGDVKLSDLIKDEDESALLEKFKRFNNGNFSSGDFFEEIKKRQGDVTGMDEFDLDLYDVFQPNEIKITYERISATYFHPAMEKKLIIAGDTSGTVGFWNVRDEPLADSEEDRMEEPDITRVKLFTKNVGRIDCFPADTSKILLTSYDGSIRSVHLNNLQSEEVLTLKNEYDDSLGISDCQFSYENPNVLFLTTLGGEFTTFDTRVKKSEYNLRRLADKKIGSMAINPMRPYEIATGSLDRTLKIWDTRNLVKKPEWSQYEDYPSHEIVSTYDSRLSVSAVSYSPTDGTLVCNGYDDTIRLFDVKSRDHLSAKLEPKLTIQHNCQTGRWTSILKARFKPNKNVFAIANMKRAIDIYNSEGQQLAHLPTATVPAVISWHPLRNWIAGGNSSGKIFLFTDDSGTIKQEE

cmr1

CRISPR system CMR subunit Cmr1

467 amino acids

CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). The CMR complex degrades RNA complementary to the crRNA (target RNA) within UA dinucleotides, generating 3'-OH and 5'-phosphate ends. Activity is dependent on the 8 nt long 5' tag in the crRNA, an unpaired 3' flag on the target RNA, and is stimulated by ATP. Some cleavage of the guide crRNA can also be observed.

Belongs to the CRISPR system Cmr1 family.

54.844 kDa

MEELLMSFKLKAIYPLTGGYNRHSINEFYEENVRPTEIKGLWRWWNRVLFNTVSYVKEGKLYTYDSIDRLFEDVFGSENKKSAVRLEVITDEGSDNHFELSNVELDNVIDCLKANREEKVNLDFRDNTLIIEIEGSTKIPISFKSNLDIDKIKDLVYKNKLLSFELLGFKSIKIDTKISDKEVIKEILRDLITNYLEYFNIKQEVTFTLNIYLDKSLKHKQNFDAKLKFALHSLLVFILLGGIGRKTSRGFGGLSIVNAECHDGLCGEIYGIVNNMESEKEKKDLATVLPNIIFSQTIEQYFSELINNESYKLRSWNNNSDFFVYYFIKDINILRINRIDTNVNRNGIENILNRISNELSASGNCLKDLIMQEMRRRAFALAFLGNRKFRNIHEIYPRILEFLYANYIKREFVNLIGKERRLSNLRFKILEINNTYYIISYLLYSSYLKDPNSSIKDTLYQFARCVI

cmr1

CRISPR system CMR subunit Cmr1

467 amino acids

CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). The CMR complex degrades RNA complementary to the crRNA (target RNA) within UA dinucleotides, generating 3'-OH and 5'-phosphate ends. Activity is dependent on the 8 nt long 5' tag in the crRNA, an unpaired 3' flag on the target RNA, and is stimulated by ATP. Some cleavage of the guide crRNA can also be observed.

Belongs to the CRISPR system Cmr1 family.

54.844 kDa

MEELLMSFKLKAIYPLTGGYNRHSINEFYEENVRPTEIKGLWRWWNRVLFNTVSYVKEGKLYTYDSIDRLFEDVFGSENKKSAVRLEVITDEGSDNHFELSNVELDNVIDCLKANREEKVNLDFRDNTLIIEIEGSTKIPISFKSNLDIDKIKDLVYKNKLLSFELLGFKSIKIDTKISDKEVIKEILRDLITNYLEYFNIKQEVTFTLNIYLDKSLKHKQNFDAKLKFALHSLLVFILLGGIGRKTSRGFGGLSIVNAECHDGLCGEIYGIVNNMESEKEKKDLATVLPNIIFSQTIEQYFSELINNESYKLRSWNNNSDFFVYYFIKDINILRINRIDTNVNRNGIENILNRISNELSASGNCLKDLIMQEMRRRAFALAFLGNRKFRNIHEIYPRILEFLYANYIKREFVNLIGKERRLSNLRFKILEINNTYYIISYLLYSSYLKDPNSSIKDTLYQFARCVI