Function
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade which results in transcriptional activation (PubMed:10428833, PubMed:12231504, PubMed:26725111). Transcriptional activation occurs at least in part through phosphorylation of crh-1 (PubMed:10428833, PubMed:12231504). Regulates gene expression, sensory morphology, and function of the AFD thermosensory neurons (PubMed:10428833, PubMed:14711416, PubMed:25467978). Involved in long-term adaptation of AFD neurons to temperatures warmer than the initial acclimatized cultivation temperature (PubMed:25467978). Acts in the FLP thermal nociceptors to moderate the responsiveness to noxious heat and controls neuropeptide release from FLP neurons in response to temperature elevations (PubMed:25467982). Regulates the dauer decision, the decision of the larvae to enter into the alternative stress-resistant and long-lived dauer developmental stage, based on the feeding state, primarily in the AWC sensory neurons. Acts non cell-autonomously in the AWC neurons to regulate expression of the daf-28 insulin-like peptide and cell-autonomously in the ASI sensory neurons to regulate expression of the growth promoting daf-7 in a food-regulated manner (PubMed:26335407). Plays a role in memory-based thermal response of an individual AFD neuron cell (PubMed:26725111). Involved in chemotaxis response in AWC neurons to attractant 2-heptanone, a volatile organic compound emitted by the nematode pathogenic bacterium B.nematocida B16 (PubMed:27660389). Represses transcription of glutamate receptor glr-1 in the nucleus basally and in response to change in synaptic activity (PubMed:27462879).
Sequence
MPLFKRRDGSGPAPNATIREKYDFRDVLGTGAFSKVFLAESKSDAGQMYAVKCIDKKALKGKEESLENEIKVLRKLRHNNIVQLFDTYDEKQFVYLVMELVTGGELFDRIVAKGSYTEQDASNLIRQVLEAVGFMHDNGVVHRDLKPENLLYYNQDEDSKIMISDFGLSKTEDSGVMATACGTPGYVAPEVLQQKPYGKAVDVWSIGVIAYILLCGYPPFYDESDANLFAQIIKGEYEFDAPYWDQISDSAKDFITHLMCCDPEARFTCQDALSHPWISGNTAYTHDIHGTVAVHLKKSLAKRNWKKAYNAAAAIRQLQMLRLSSNSNRLQKQASQQQPEPPTPAFHA