cmasa

Gene

cmasa

Protein

N-acylneuraminate cytidylyltransferase A

Organism

Danio rerio

Length

430 amino acids

Function

Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Also has activity towards N-glycolylneuraminic acid (Neu5Gc). Has weak activity towards 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).

Similarity

Belongs to the CMP-NeuNAc synthase family.

Mass

48.227 kDa

Sequence

MDAVNENGKRAMKDDSHGNSTSPKRRKSRHISALILARGGSKGIPLKNIKMLAGVPLIGWVIRAAVDSNVFNSVWVSTDHEEIAKVALAWGAKVHKRSPEVSQDSSSSLDTIREFSRQHREVDVICNIQATSPCLHPKHLTEAVELITKQGYDSVFSVVRRHNFRWKEVEKGGDCSTEPMNLNPACRPRRQDWSGELCENGSFYFAKKELIEQGLLQGGKKTYYEMKPEYSVDIDVDIDWPVAEQRVLRFGYFGKDKPEVVRLLLCNVSGCLTDGQIYTSASGEEMVSINIRDQIGISMLKKEGVKVILLETYPIAKALAVRLSERMGCPLLHHMDDKLKEVERIMVEEKLEWKEVAYLGNDEADVKCLELAGLSGVPVDAPTVALNHTKYTCHNAAGHGAVREFAEHILLLKKKAKSQMEQDRICRDAF

Protein

N-acylneuraminate cytidylyltransferase A: cmasa