Protein
Telomere length regulation protein clk-2
Organism
Caenorhabditis elegans
Function
DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability (PubMed:10882129, PubMed:16951081). Regulator of telomere length (PubMed:11696330, PubMed:11641227).
Similarity
Belongs to the TEL2 family.
Sequence
MNLRSRLVNATERAVLFQIFKDVQNDPEKYDNAVEAICESIDYFGKFLTDSEYLTQIKPILDTQCPTKSIICFSKCLTKVSTDINTTTFRDVITMLDWLKYVVEKSLTSAICSSLKVKETDVSAVQLYREFASACSNIPEKVSNCCAKALSGEHVKYINTVKWIFKMNLVQGIQKAMLLAHDDIVTAAPFTSFYGSGGPYMKTVAEIISSGRNIDITNKDGLLVQMIEWIGSLNNFDSQWRRMMFLIFQEPTYQGIQVHESLLTTLFLISKSDQILKRCIEATDLTGTLKRVVMVKLPFQRVLKRKTIEILINFVYRTKEQFAIQLLETSVKIWSDLNYAKSAPESQERHIVRMILYLVHLFRTCSSIDWESLFLNSMDGVHCRMSMLPMYVQSGIFVNQALCKQATKHRSKTHGSDEQPPETLEENKFVSSEVGKIWFEEMTSILEHGFNSSTVKDSERVRETANEITKDDSGEEFEETNAQRLQNNKDSAAITSKNNLRLDSDDDEDFPDYQVNESEKIFKNLEIGEEPKNKVTPPAYIADAFEMLLEKEKYEVFEAAFFNITNLINRRPIGFPQIAEKLFIRILHLQNNFGTPKFKETVDEIAVACITQRPEIVPSVVRLIIAPGQGFSIKQRLLHYIHNAADGMGALDKKLEECVMAQQLRIGGPTLSIILHRTINTDYDDEDEDPHRLLVPEWRRMVDARIAANTRRIGTTREPPRAGVVNRLAQAAKYMFYPLLVLPRGENASLLGKDSDLLASLIMVASMVYVRCGVCPQIHRMSSELISYATPHRFSENAKLRTACIIAHLNVTTLLPGDLMDELFDVPALIGWFDWANSVLVNASSSQLEKDMTRQFGHSVTKHLQRYHPAVLQHQDV