Protein
Calcium homeostasis modulator protein
Organism
Caenorhabditis elegans
Function
Pore-forming subunit of a voltage-gated ion channel. Permeable to monovalent cations, divalent cations and anions with selectivity Ca(2+) > Mg(2+) > Na(+) = K(+) > Cl(-). Acts both as a voltage-gated and calcium-activated ion channel. Required for normal locomotion.
Similarity
Belongs to the CALHM family.
Sequence
MTTSINSVVTVFQNVFTNHGSTLLNGILIATTVGGQSLVRKLTFSCPCAYPLNIYHSLVFMFGPTAALLLIGITVNSTTWKLAHGFFFRVRDTRHSWKTTCVSWIEVLIQSSVAPIAWLFVVFLDGGYYRCYRSHEFCLISDAILCKNSTILNSYASTSSFNKISDNGKYCPPCICVPNPTDASYLEAESQIYAWGLLLFSGVAAFLVITCNRMCDKYTLVQRQYVETYKNVETQKFDAVAKEHASQLAEHNARAFFGQKDWTKRDWDWVSGIPEVNNPLFARLRLIAAEKTQQTMYTPLQLWNDNKGYRIPQPDLQLTQIIVDETKED