cldB

Gene

cldB

Protein

Copalyl diphosphate synthase

Organism

Streptomyces cyslabdanicus

Length

532 amino acids

Function

Involved in the biosynthesis of the mercapturic acid derivative diterpene cyslabdan A, a potentiator of the beta-lactam antibiotic imipenem (PubMed:26507838). Catalyzes the conversion of geranylgeranyl diphosphate (GGDP) into (+)-copalyl diphosphate (PubMed:26507838, PubMed:26814669).

Similarity

Belongs to the terpene synthase family.

Mass

56.819 kDa

Sequence

MSSISHQAAPTRAQHTNSYVQLARQLVTSVDNDPWGDVPPSVYETARVTSWAPWLEGHERRLAWLLERQSAAGSWGEGPTPYRLLPTLSVTEALLSTLRQNTAAGVSRERLAAAVDNGLAALRDLSGTGGWPDTAAIEILAPDLVVLINDHLDQPEVAALPRLGPWARGQRLAQPHGFQAALPDRVAERCQVAGGVPLKLHHTFEGVARRLPRMVPGVPGGLLGSSPAATAAWLATGPDEGRDQAVTALTAVAERYDGLFPEATPISVFERLWISVALARPGLPAACVPTIRAWAAEIYDATGVRGAPGLLPDTDDTAMAVLASALAGSPRDPSPLSAFEAGDHYDCYVGEDTGSSTANAHALQALTAWLSHRPATGDALQARRDLTRDWLLAQQESDGAWRDKWHASPYYATERCVTALSGHTGPTTRDAIRSAADWVLDAQSDDGSWGVWGGTAEETAYAVNILLNSPDHTGTPEATQALKLAENVLREAVHSSGHHHPALWHDKTLYAPQAMAQAEVIAALELLQARRP

Protein

Copalyl diphosphate synthase: cldB