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citE

Gene
citE
Protein
Citrate lyase subunit beta
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Length
302 amino acids
Function
Represents a citryl-ACP lyase.
Similarity
Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit subfamily.
Mass
33.11 kDa
Sequence
MISASLQQRKTRTRRSMLFVPGANAAMVSNSFIYPADALMFDLEDSVALREKDTARRMVYHALQHPLYRDIETIVRVNALDSEWGVNDLEAVVRGGADVVRLPKTDTAQDVLDIEKEILRIEKACGREPGSTGLLAAIESPLGITRAVEIAHASERLIGIALGAEDYVRNLRTERSPEGTELLFARCSILQAARSAGIQAFDTVYSDANNEAGFLQEAAHIKQLGFDGKSLINPRQIDLLHNLYAPTQKEVDHARRVVEAAEAAAREGLGVVSLNGKMVDGPVIDRARLVLSRAELSGIREE

Gene
citE
Protein
Citrate lyase subunit beta
Organism
Escherichia coli (strain K12)
Length
302 amino acids
Function
Represents a citryl-ACP lyase.
Similarity
Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit subfamily.
Mass
33.11 kDa
Sequence
MISASLQQRKTRTRRSMLFVPGANAAMVSNSFIYPADALMFDLEDSVALREKDTARRMVYHALQHPLYRDIETIVRVNALDSEWGVNDLEAVVRGGADVVRLPKTDTAQDVLDIEKEILRIEKACGREPGSTGLLAAIESPLGITRAVEIAHASERLIGIALGAEDYVRNLRTERSPEGTELLFARCSILQAARSAGIQAFDTVYSDANNEAGFLQEAAHIKQLGFDGKSLINPRQIDLLHNLYAPTQKEVDHARRVVEAAEAAAREGLGVVSLNGKMVDGPVIDRARLVLSRAELSGIREE

Gene
citE
Protein
Citrate lyase subunit beta
Organism
Leuconostoc mesenteroides subsp. cremoris
Length
302 amino acids
Function
Represents a citryl-ACP lyase.
Similarity
Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit subfamily.
Mass
33.376 kDa
Sequence
MNNERLRRTMMFVPGNNPAMVKDAGIFGADSIMFDLEDAVSLAEKDSARYLVYEALQTVDYGSSELVVRINGLDTPFYKNDIKAMVKAGIDVIRLPKVETAAMMHELESLITDAEKEFGRPVGTTHMMAAIESALGVVNAVEIANASDRMIGIALSAEDYTTDMKTHRYPDGQELLYARNVILHAARAAGIAAFDTVFTNLNDEEGFYRETQLIHQLGFDGKSLINPRQIEMVNKVYAPTEKEINNAQNVIAAIEEAKQKGSGVISMNGQMVDRPVVLRAQRVMKLANANHLVDSEGNYIEK

Gene
citE
Protein
Short chain dehydrogenase citE
Organism
Monascus ruber
Length
292 amino acids
Function
Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of the mycotoxin citrinin, a hepato-nephrotoxic compound to humans due to inhibition of respiration complex III (Ref.1). The pathway begins with the synthesis of a keto-aldehyde intermediate by the citrinin PKS (pksCT also named citS) from successive condensations of 4 malonyl-CoA units, presumably with a simple acetyl-CoA starter unit (Ref.1). Release of the keto-aldehyde intermediate is consistent with the presence of the C-terminal reductive release domain (Ref.1). The exact catalytic role of the hydrolase citA remains mysterious, although it is clear that it increases the productivity of the PKS and performs the earliest non-PKS step during citrinin biosynthesis (Ref.1). CitB then catalyzes the oxidation of the C-12 methyl of the ketone intermediate to an alcohol intermediate which is further oxidized by the oxidoreductase citC to produce a bisaldehyde intermediate (Ref.1). The fourth catalytic step is catalyzed by the citD aldehyde dehydrogenase (Ref.1). The final transformation is the reduction of C-3 by citE to provide the chemically stable citrinin nucleus (Ref.1). CitE appears highly selective for its substrate as its presence in any context other than a full complement of citS and citA-D does not result in observable new compounds (Ref.1).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
31.351 kDa
Sequence
MAFPPSAGFTWISKTHNDTYPTITAAKCKQHGRAVFVTGASKGIGRVTAVAFAQAGAPSLALGARSSLDAAETAVLDAAKSAGHPPPQVLKLTLDVADEQSVADAAARVERAFGRLDILVNNAGRVEKWVPLAETDPKSWWATWEVNLKGTYLMTRAMLPLLLKGGEKTIVNMNSIGAHLTRPGASAYQTGKLAMLRLTQFTCVEYAAQGVLAFAIHPGAVDTELASNLPEDTKAKLVDSPELCADTIVWLTQEKQSWLAGRYLSANWDVAELMARKEEILQGDKLKVKLVL

Gene
citE
Protein
Citrate lyase subunit beta
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
291 amino acids
Function
Represents a citryl-ACP lyase.
Similarity
Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit subfamily.
Mass
31.855 kDa
Sequence
MKLRRSMLFVPGSNAAMLSNSFIYKPDSIMFDLEDAVALKEKDSARLLVAHALQHPLYKEIETVVRVNPLDSEFGLLDLNSVVRAGVDVVRMPKTESAQDVLDMDHAITEIEKACGREAGSTKMLAAIESPLGITQANQIAFASKRLIGIALGAEDYVRNLKTERSPEGIELLFARCSILQAARAAGIQAFDTVYSNANNEEGFLKEAALIKQLGFDGKSLINPRQIELLHNLFAPTQKDVEQAKRIIEAAVEAERQGAGVVSLNGKMIDAPIIDRAKLVLERAKSGIREE

Gene
citE
Protein
Citrate lyase subunit beta
Organism
Klebsiella pneumoniae
Length
289 amino acids
Function
Represents a citryl-ACP lyase.
Similarity
Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit subfamily.
Mass
31.352 kDa
Sequence
MKPRRSMLFIPGANAAMLSTSFVYGADAVMFDLEDAVSLREKDTARLLVYQALQHPLYQDIETVVRINPLNTPFGLADLEAVVRAGVDMVRLPKTDSKEDIHELEAHVERIERECGREVGSTKLMAAIESALGVVNAVEIARASPRLAAIALAAFDYVMDMGTSRGDGTELFYARCAVLHAARVAGIAAYDVVWSDINNEEGFLAEANLAKNLGFNGKSLVNPRQIELLHQVYAPTRKEVDHALEVIAAAEEAETRGLGVVSLNGKMIDGPIIDHARKVVALSASGIRD

Gene
citE
Protein
Citrate lyase subunit beta-like protein
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
273 amino acids
Function
May play a role in fatty acid biosynthesis.
Similarity
Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit-like subfamily.
Mass
28.886 kDa
Sequence
MNLRAAGPGWLFCPADRPERFAKAAAAADVVILDLEDGVAEAQKPAARNALRDTPLDPERTVVRINAGGTADQARDLEALAGTAYTTVMLPKAESAAQVIELAPRDVIALVETARGAVCAAEIAAADPTVGMMWGAEDLIATLGGSSSRRADGAYRDVARHVRSTILLAASAFGRLALDAVHLDILDVEGLQEEARDAAAVGFDVTVCIHPSQIPVVRKAYRPSHEKLAWARRVLAASRSERGAFAFEGQMVDSPVLTHAETMLRRAGEATSE

Gene
citE
Protein
Citrate lyase subunit beta-like protein
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
273 amino acids
Function
May play a role in fatty acid biosynthesis.
Similarity
Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit-like subfamily.
Mass
28.886 kDa
Sequence
MNLRAAGPGWLFCPADRPERFAKAAAAADVVILDLEDGVAEAQKPAARNALRDTPLDPERTVVRINAGGTADQARDLEALAGTAYTTVMLPKAESAAQVIELAPRDVIALVETARGAVCAAEIAAADPTVGMMWGAEDLIATLGGSSSRRADGAYRDVARHVRSTILLAASAFGRLALDAVHLDILDVEGLQEEARDAAAVGFDVTVCIHPSQIPVVRKAYRPSHEKLAWARRVLAASRSERGAFAFEGQMVDSPVLTHAETMLRRAGEATSE