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cic-1

Gene
cic-1
Protein
Cyclin-C
Organism
Caenorhabditis elegans
Length
302 amino acids
Function
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase cdk-8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
Similarity
Belongs to the cyclin family. Cyclin C subfamily.
Mass
35.013 kDa
Sequence
MALNFWKSSHCQQWIFDKTEIWKQRAEDMKIYNEEEYNRLNIFWANFITAVATEGAHSQANVGCKLRQQVIATAIIYFKRFYLRQSFRDMCPFLVASTALFLACKVEEHTTLSVSSFLKNTAIVLPKRWGVTFETTSTKNGVVYDSEFILVEILDCCLVVHHASRPMFELLEDLKQFTQQSTIANQPIKDLEAIEAQCQKVANDSLRCDVSLIFPPHVIGLSSIMVAMELMGRGEELEAWLVEVDTDFEKVTDCVEQIYKMYTLWKSFDEKEEVKKLMAKLPKPNQQPPPQQQHQHQQGYHL

Gene
cic-1
Protein
Cyclin-C
Organism
Caenorhabditis briggsae
Length
298 amino acids
Function
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase cdk-8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
Similarity
Belongs to the cyclin family. Cyclin C subfamily.
Mass
34.463 kDa
Sequence
MALDFWKSSHAQQWIFDKTEIWKQRAEDMKTYSEEEYSRLNIFWANFITAVATECAHSQANVGCKLRQQVIATAIVYFKRFYLRQSFRDMCPFLVASTALFLACKVEEHTTLSVSSFLKNTALVLPKRWGVAFETNSAKNGVLYDSEFILVEILDCCLVVHHATRPMFELLEDWKQHTLTSTNTPVKDFDQIEIQCQKVVNDTLRCDVGLMFAPHCIGLASISVGMELMGRGEELEDWLVEVDTDMDKLADCINQIYTMYQLWRSFDEKEEVKKLMAKLPKPNTPIPPPQQQQSSYHM