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ciapin1-A

Gene
ciapin1-A
Protein
Anamorsin-A
Organism
Salmo salar
Length
313 amino acids
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
Similarity
Belongs to the anamorsin family.
Mass
33.142 kDa
Sequence
MADLGVKAGDKVLLVWSQPSSPTTLKKLAESLGAMVGTDGRVSLENMERLIMSSHAASSYDWVLSSLLSDSFSVHTSETLAEMARVIKPDGKLVLEEPVTGTDDQKVRTAEKLISALKLSGLVSVTEVSKEPLTPEAVSALKTFTGFQGNTLSRVRMSASKPNFEVGSSSQLKFSFGKKTSKPVDKPALDPNAAKAWTLSANDMDDDDVDLVDSDALLDADDFKKPDAASLKAPSCGDGTTKKKKACKNCSCGLAEELEQESKGAKTISQPKSACGSCYLGDAFRCASCPYIGMPAFKPGEKIVLANTGLNDT