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ciao2B

Gene
ciao2B
Protein
Cytosolic iron-sulfur assembly component 2B
Organism
Dictyostelium discoideum
Length
163 amino acids
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. May play a role in chromosome segregation through establishment of sister chromatid cohesion.
Similarity
Belongs to the MIP18 family.
Mass
18.494 kDa
Sequence
MSDNPNPVIYVDNENCKSFEDNENSFNSSRYSIEEDQIDEFDEQEIFDLVRSITDPEHPLTLEQLNVVRIENVNINLENSYILLYFTPTVPHCSMANLIGLSIKEKLARSLPKRFKVDVIVTPGSHSSESSVNKQLNDKERVSAALDTSSSILTIVNECIKQN

Gene
CIAO2B
Protein
Cytosolic iron-sulfur assembly component 2B
Organism
Homo sapiens
Length
163 amino acids
Function
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004, PubMed:22678362, PubMed:22678361). As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins (PubMed:23891004). As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633).
Similarity
Belongs to the MIP18 family.
Mass
17.663 kDa
Sequence
MVGGGGVGGGLLENANPLIYQRSGERPVTAGEEDEQVPDSIDAREIFDLIRSINDPEHPLTLEELNVVEQVRVQVSDPESTVAVAFTPTIPHCSMATLIGLSIKVKLLRSLPQRFKMDVHITPGTHASEHAVNKQLADKERVAAALENTHLLEVVNQCLSARS

Gene
Ciao2b
Protein
Cytosolic iron-sulfur assembly component 2B
Organism
Mus musculus
Length
163 amino acids
Function
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD.
Similarity
Belongs to the MIP18 family.
Mass
17.667 kDa
Sequence
MVGGGGSGGGLLENANPLIYERSGERPVTAGEEDEEVPDSIDAREIFDLIRSINDPEHPLTLEELNVVEQVRIQVSDPESTVAVAFTPTIPHCSMATLIGLSIKVKLLRSLPQRFKMDVHITPGTHASEHAVNKQLADKERVAAALENTHLLEVVNQCLSARS