Protein
Acetylcholine receptor subunit alpha-1-A
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Similarity
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.
Sequence
MDFVLTRLILLFLAATIIYSSEDESRLINDLFKSYNKVVRPVKAFKDKVVVTVGLQLIQLINVNEVNQIVTTNVRLKQQWEDVHLKWDPEDYGGIKKVRIPSSDIWRPDIVLYNNADGDFAIVQETKVLLDYTGKIIWLPPAIFKSYCEMIVTYFPFDLQNCSMKLGTWTYDGTLVVINPENDRPDLSNFMESGEWYMKDYRCWKHWVYYDCCPETPYLDITYHFLLQRLPLYFIVNVVIPCLLFSFLTGLVFYLPTDSGEKITLSVSVLLSLVVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIVITVIVINTHHRSPSTHIMPQWLKKIFIETIPRVMFFSTMKRPAQDQHKKKIFTEDIDISDISGKLGPTAVKYQSPILKNPDVKSAIEGAKYVAETMKSDQESTKASEEWKFVAMVLDHLLLAVFMIVCIIGTLAIFAGRLIELHMQG