Protein
Phosphatidylethanolamine N-methyltransferase
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Function
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
Similarity
Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
Sequence
MDRGLSTGTNQSGAGLRERAVTSQADLNVITENPTVTNASNGKDKAGKTFGRTPDGTVFTVPQTHDMVSQLLSPSEPKNLSDLVVLTILAGHIFLLWILPSGAKIPVFAVIYLFWRSCYNAGIGWLLHNQSHHKTLVRWAEKSQIFVNPATGKNPYPQLYHLIKRELEIKISKDYSFEEAPLEYNTWLVFRRLVDLILMCDFASYCLFAIACSRHPANESVLMTVIRWTSGIALVLFNLWVKLDAHRVVKDYAWYWGDFFYLIDQELTFDGVFEMAPHPMYSVGYAGYYGISLMAASYKVLFISIIAHAAQFAFLVLVENPHIDKTYNPPPPRKRTITEHDAASQRSQSPDTPNAPSVSEENVPNATTFSSPPPAVHNLLGFHNLDLHRITDTSSILVQFLMFSLTVLTPSTPWYQFLFVANAAIWRLWYSVGIGYLLNRQSNCKSWTRHFVKYGETPHEAWNQWKGTYHLSMVMCYASFISAVWKMYTLPSNWGYGLAILRHVLGAGLISLQIWTSVSIYESLGEFGWFYGDFFFDESPKLTYNGIYRFLNNPERVLGLAGVWGAVLITASGTVAFLAFLSHILSLGFIQFVERPHMQKLYGRSLRQDAGLVKSLKRSLPPSLRQLHGSVDKIFDESYEFIEEIIDTARPKLAAGVNTFVRDTTALFQKYPARVTISRIDADLAGYDLRDYSLTVEASQLPLDEGDLSKEGDNARTPLDRRGDLENLVFPYGTPVKVKWTAPLNHSKKDWIGLYKVTDNTSREVTRVSSQGRWVAVNEGFYDNLTCERGILISDVVVSTSQGDNGEKHDIATGEVVFSGDKLFWTQGVFEFRYHHNGKHNVMAISRPFEVRIPRFEEEDHFDMSQTAVETSLLPVIQNCFDRDPEIAPETPEEQYGSLVERDGKFAKRVVFAVHQMFGVEFAPEVVRSDGNVRNLAWRICNAKRVLAPYSMSRDGATTPTESKE