Protein
Charged multivesicular body protein 2b-A
Function
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
Similarity
Belongs to the SNF7 family.
Sequence
MASLFKKKTVDDIIKDQNKELKGQQRAITRDRTALEKQEKQLEMEIKKMAKAGNKDACKVLAKQLVQLRKQKTRTYAVSSKVTSMSTQTKVMSSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDASEDEEESQDIVNQVLDEIGIEISGKMAKAPSAAKGLPSASASKSTGISDEEIERQLKALGVD