Protein
Charged multivesicular body protein 2a homolog 2
Organism
Dictyostelium discoideum
Function
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).
Similarity
Belongs to the SNF7 family.
Sequence
MFLFGKQKTPKEVLRENQRNLNKSMREIDRERVALQNQEKKIILDIKKMAKQGQMNSAKIMAKDLVRTRYHIQKFYEMKTQLQAVSLRIQTLQSTQAMAEAMKGVTKAMITMNRQMNLPQFTKIMMEFEQQSDKMDMKEEMMNDTMDQVMEQDGEEEQSQEILNQVLDEIGIDLASQLVDAPTTVGTSVASKHQVNSG