Protein
Structure-specific endonuclease subunit SLX1 homolog
Organism
Cryptosporidium parvum (strain Iowa II)
Function
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Similarity
Belongs to the SLX1 family.
Sequence
MKSNIQLHYCYFLLSEAKKKASYIGYSVNPCRRLRQHNGEIKKGAKKTKSGVPWNLGICVGGFPDRVAALRFEWAWQHPNICKVTRDNIESWKIVKTKKTSENKRILNKRQWSIQQRVSILLCMTTLEPWKNMNLTVFVFKDELENTIKEVIEGIKKIKISPNFTSPNILNKDYLLMFLYFGEDSFYEKGIKFLRCDYETFKEFQKPSFDCDSDSNIEDNSNVFNPEEIISHEDSFSIKCFLCQKDIGIGRNYLEFPCCTEIKVHLSCIQLWGESNNHLETVIDELFPLKEFVAPLIPLNISCPCCFKDFEWEEAKKNYIKTKNVPTESLELGEDFPVLSNGEKENYSQEENSQNKVIEDGFLEMDIDNHRNRLSYAHETKQKRDILFSDDEFSEISQKCEFIDLTVDSD