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cfr

Gene
cfr
Protein
Ribosomal RNA large subunit methyltransferase Cfr
Organism
Bacillus clausii (strain KSM-K16)
Length
350 amino acids
Function
Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics.
Similarity
Belongs to the radical SAM superfamily. RlmN family. Cfr subfamily.
Mass
39.857 kDa
Sequence
MKVVNHATKYERLKHFLNALNEPTYRYKQITEAIFKHRIGAFNKMTTLPKALRESLINEFGPSILTVEPVLETTSQQVTKVLLKVAGNNQVEAVRMHYEAGWESFCISSQCGCGLGCTFCSTGAIGLKQNLSADEMTDQLLYFYLKGHSLDSVSFMGMGEALANVRIFDALNVLVDRQLFALSPRRITVSTVGIIPNIQRMTSSFPQMNLTFSLHSPFHDQRSELMPINNKYPLDQVMNVLDQHIHETGRKVYIAYVMLRGVNDSEKHAEALVKRILNNRYPHLYHVNLIRYNPTVGTPENYGQTIEEKLQTFYRVVKSARIPVTIRSQFGREIDAACGQLYGQYQAKKR

Gene
cfr
Protein
Ribosomal RNA large subunit methyltransferase Cfr
Organism
Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42)
Length
349 amino acids
Function
Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics.
Similarity
Belongs to the radical SAM superfamily. RlmN family. Cfr subfamily.
Mass
40.078 kDa
Sequence
MQQKNKYIRIQEFLKQNKFPDFRMNQIKNAVFQGRINHFNEITVLPKSLRKLLIEEFGESILNIAPLKVQHSEQVTKVLFEISGDEKIETVNMKYKAGWESFCISSQCGCHFGCKFCATGDIGLKRNLTSDEMTDQILYFHLKGHSIDSISFMGMGEALANVQVFDALHVLTNPELFALSPRRLSISTIGIIPGIKKITQDYPQVNLTFSLHSPFNEQRSKLMPINERYPLLEVMDTLDEHIRVTSRKVYIAYIMLPGVNDSIDHANEVVNLLRSRYKRGNLFHVNIIRYNPTVSSPMRFEEVNEKQVVNFYKKLKSAGINVTVRSQFGIDIDAACGQLYGNYQKNKNQ

Gene
cfr
Protein
Ribosomal RNA large subunit methyltransferase Cfr
Organism
Staphylococcus aureus
Length
349 amino acids
Function
Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics, such as chloramphenicol, florfenicol, clindamycin and linezolid.
Similarity
Belongs to the radical SAM superfamily. RlmN family. Cfr subfamily.
Mass
39.862 kDa
Sequence
MNFNNKTKYGKIQEFLRSNNEPDYRIKQITNAIFKQRISRFEDMKVLPKLLREDLINNFGETVLNIKLLAEQNSEQVTKVLFEVSKNERVETVNMKYKAGWESFCISSQCGCNFGCKFCATGDIGLKKNLTVDEITDQVLYFHLLGHQIDSISFMGMGEALANRQVFDALDSFTDPNLFALSPRRLSISTIGIIPSIKKITQEYPQVNLTFSLHSPYSEERSKLMPINDRYPIDEVMNILDEHIRLTSRKVYIAYIMLPGVNDSLEHANEVVSLLKSRYKSGKLYHVNLIRYNPTISAPEMYGEANEGQVEAFYKVLKSAGIHVTIRSQFGIDIDAACGQLYGNYQNSQ

Gene
cfr
Protein
Ribosomal RNA large subunit methyltransferase Cfr
Organism
Staphylococcus sciuri
Length
349 amino acids
Function
Specifically methylates position 8 of adenine 2503 in 23S rRNA. Can also methylate position 2 of A2503 after the primary methylation at position 8 is complete, to form 2,8-dimethyladenosine; however, C8 is its preferred target. Confers resistance to several classes of antibiotics such as phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A. The antibiotic resistance conferred by Cfr is provided by methylation at the 8 position and is independent of methylation at the 2 position of A2503.
Similarity
Belongs to the radical SAM superfamily. RlmN family. Cfr subfamily.
Mass
39.862 kDa
Sequence
MNFNNKTKYGKIQEFLRSNNEPDYRIKQITNAIFKQRISRFEDMKVLPKLLREDLINNFGETVLNIKLLAEQNSEQVTKVLFEVSKNERVETVNMKYKAGWESFCISSQCGCNFGCKFCATGDIGLKKNLTVDEITDQVLYFHLLGHQIDSISFMGMGEALANRQVFDALDSFTDPNLFALSPRRLSISTIGIIPSIKKITQEYPQVNLTFSLHSPYSEERSKLMPINDRYPIDEVMNILDEHIRLTSRKVYIAYIMLPGVNDSLEHANEVVSLLKSRYKSGKLYHVNLIRYNPTISAPEMYGEANEGQVEAFYKVLKSAGIHVTIRSQFGIDIDAACGQLYGNYQNSQ

Gene
cfr
Protein
Ribosomal RNA large subunit methyltransferase Cfr
Organism
Staphylococcus warneri
Length
349 amino acids
Function
Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics.
Similarity
Belongs to the radical SAM superfamily. RlmN family. Cfr subfamily.
Mass
39.862 kDa
Sequence
MNFNNKTKYGKIQEFLRSNNEPDYRIKQITNAIFKQRISRFEDMKVLPKLLREDLINNFGETVLNIKLLAEQNSEQVTKVLFEVSKNERVETVNMKYKAGWESFCISSQCGCNFGCKFCATGDIGLKKNLTVDEITDQVLYFHLLGHQIDSISFMGMGEALANRQVFDALDSFTDPNLFALSPRRLSISTIGIIPSIKKITQEYPQVNLTFSLHSPYSEERSKLMPINDRYPIDEVMNILDEHIRLTSRKVYIAYIMLPGVNDSLEHANEVVSLLKSRYKSGKLYHVNLIRYNPTISAPEMYGEANEGQVEAFYKVLKSAGIHVTIRSQFGIDIDAACGQLYGNYQNSQ

Gene
cfr
Protein
Ribosomal RNA large subunit methyltransferase Cfr
Organism
Clostridium botulinum (strain ATCC 19397 / Type A)
Length
344 amino acids
Function
Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics.
Similarity
Belongs to the radical SAM superfamily. RlmN family. Cfr subfamily.
Mass
39.161 kDa
Sequence
MKQTKTKYGKMKQIASNLKLPDYRYEQLTKAIFHQRIDNFHDMHILPKALRIALVNEFGKNVSSVTPIFSQDSKQAQKLLFELTDGERIEAVGLKYKQGWESFCISSQCGCSFGCRFCATGSAGFKRNLTADEITDQLLYFYFNDHRLNSISFMGMGEAFANPELFDAVKILTDQNLFGLSQRRITISTIGIIPGIQRLTKEFPQVNLAFSLHSPFESQRSDLMPINKRFPLNEVMKTLDEHIIHTGRRVFIAYIMLEGINDSKEHAEAIIGLLRNRGSWEHLYHIDLIPYNSTDKTTFKFQSSSAIKQFCSTLKKASISATVRTQFGSEISAACGQLCYENEL

Gene
cfr
Protein
Ribosomal RNA large subunit methyltransferase Cfr
Organism
Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
Length
344 amino acids
Function
Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics.
Similarity
Belongs to the radical SAM superfamily. RlmN family. Cfr subfamily.
Mass
39.161 kDa
Sequence
MKQTKTKYGKMKQIASNLKLPDYRYEQLTKAIFHQRIDNFHDMHILPKALRIALVNEFGKNVSSVTPIFSQDSKQAQKLLFELTDGERIEAVGLKYKQGWESFCISSQCGCSFGCRFCATGSAGFKRNLTADEITDQLLYFYFNDHRLNSISFMGMGEAFANPELFDAVKILTDQNLFGLSQRRITISTIGIIPGIQRLTKEFPQVNLAFSLHSPFESQRSDLMPINKRFPLNEVMKTLDEHIIHTGRRVFIAYIMLEGINDSKEHAEAIIGLLRNRGSWEHLYHIDLIPYNSTDKTTFKFQSSSAIKQFCSTLKKASISATVRTQFGSEISAACGQLCYENEL

Gene
cfr
Protein
Ribosomal RNA large subunit methyltransferase Cfr
Organism
Clostridium botulinum (strain Okra / Type B1)
Length
344 amino acids
Function
Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics.
Similarity
Belongs to the radical SAM superfamily. RlmN family. Cfr subfamily.
Mass
39.109 kDa
Sequence
MKQTKTKYGKMKQMVSNLKLPDYRYEQLTKAIFHQRIDNFDDIHILPKALRMSLVNEFGKNVSSVIPVFSQDSKQAQKLLFELTDGERIEAVGLKYKQGWESFCISSQCGCGFGCRFCATGSAGFKRNLTADEITDQLLYFYFNNHRLNSISFMGMGEAFANPELFDAVKILTDQNLFGLSQRRITISTIGIIPGIQRLTKKFPQVNLAFSLHSPFESRRSDLMPINKRFPLNEVMKTLDEHIIHTGRRVFIAYIMLEGINDSKEHAEAVVGLLKNRGSWEHLYHIDLIPYNSTDKTTFKFQSSSAIKQFCSTLKKAGISATVRTQFGSEISAACGQLCYENEL

Gene
cfr
Protein
Ribosomal RNA large subunit methyltransferase Cfr
Organism
Clostridium botulinum (strain Langeland / NCTC 10281 / Type F)
Length
344 amino acids
Function
Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics.
Similarity
Belongs to the radical SAM superfamily. RlmN family. Cfr subfamily.
Mass
39.067 kDa
Sequence
MKQTKTKYGKMKQIVSNLKLPDYRYEQLTKAIFHQRIDNFDDMHILPKVLRMSLVNEFGKNVSSVIPVFSQDSKQAQKLLFELTDGERIEAVGLKYKQGWESFCISSQCGCGFGCRFCATGSAGFKRNLTADEITDQLLYFYFNDHRLNSISFMGMGEAFANPELFDAVKILTDQNLFGLSQRRITISTIGIIPGIQSLTQKFPQVNLAFSLHSPFESQRSDLMPINKRFPLNQVMKTLDEHIIHTGRRVFIAYIMLEGINDSKEHAEAVVGLLKNRGSWEHLYHIDLIPYNSTDKTTFKFQSSNAIKQFCSTLKKAGISATVRTQFGSEISAACGQLCYENEL

Gene
cfr
Protein
Ribosomal RNA large subunit methyltransferase Cfr
Organism
Clostridium botulinum (strain Loch Maree / Type A3)
Length
344 amino acids
Function
Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics.
Similarity
Belongs to the radical SAM superfamily. RlmN family. Cfr subfamily.
Mass
39.109 kDa
Sequence
MKQTKTKYGKMKQMVSNLKLPDYRYEQLTKAIFHQRIDNFDDIHILPKALRMSLVNEFGKNVSSVIPVFSQDSKQARKLLFELTDGERIEAVGLKYKQGWESFCISSQCGCGFGCRFCATGSAGFKRNLTADEITDQLLYFYFNNHRLNSISFMGMGEAFANPELFDAVKILTDQNLFGLSQRRITISTIGIIPGIQRLTKKFPQVNLAFSLHSPFESQRSDLMPINKRFPLNEVMKTLDEHIIHTGRRVFIAYIMLEGINDSKEHAEAVVGLLKNRGSWEHLYHIDLIPYNSTDKTTFKFQSSSAIKQFCSTLKKAGISATVRTQFGSEISAACGQLCYENEL

Gene
cfr
Protein
Ribosomal RNA large subunit methyltransferase Cfr
Organism
Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg)
Length
344 amino acids
Function
Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics.
Similarity
Belongs to the radical SAM superfamily. RlmN family. Cfr subfamily.
Mass
38.651 kDa
Sequence
MNYSKYETMKQLIADMKLPDYRYEQIIKAIFSQHTSTFEKMSTLPLELKKSLINTFGPSVCCTVPVACQTSGQADKILFSLPDGNRVETVNLHYKKGWESFCISSQCGCGFGCQFCATGTLGHKRNMTADEITDQLLYFHLNGHKLNSISFMGMGEPLANPNLFDALNILNDSSLFGLSQRRITISTIGIIPGIKRLTHEFPQINLAYSLHSPFENQRSELMPVNRSFPLHEVMNALDNHIRHTGRRLFLAYIMLNGVNDSVDHAKALVELLQDRGPWAHLYHVDLIPYNATDKTPRKFASSDKITMKRFRDILHANGISVATRTQFGSDISAACGQLLGEKDV