Protein
Cilia- and flagella-associated protein 298-A
Function
Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:26904945). Seems to be important for initiation rather than maintenance of cilium motility (By similarity). Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (PubMed:26904945). May suppress canonical Wnt signaling activity (PubMed:26904945).
Similarity
Belongs to the CFAP298 family.
Sequence
MVRLHVKKGDESQFLFDTSVTVPVEELVKQITAIYNGRLKIDRICSEMGELAEHGITMPPNMQGLADEQIEELKLKDEWEERCVPSGGSVFKKDEIGRRNGHAPSDSMKKVLQKTMEEAKALISKKQAEANVCVTLEMVKEATDQLRGAVMIVYPMGLPPHDPIRMEFENNEDLSGTHAGQLVIEEPESQLWWAGKELQRKQKLSDYVGKNEKTRIIVKIQKRGQGAPAREPVITQEEQKKLMMHYYRRQEEFKKLEEDEDISYLNAEWADSNSLKRQFQGVKDIKWKPR