Protein
Cilia- and flagella-associated protein 298
Function
Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:24094744, PubMed:26904945). Seems to be important for initiation rather than maintenance of cilium motility (PubMed:26904945). Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (PubMed:26904945). May suppress canonical Wnt signaling activity (PubMed:26904945).
Similarity
Belongs to the CFAP298 family.
Sequence
MVQLHVKRGDESQFLFNTTVDVQIETLTQQICEIYNARLKVDRICTEIPELADHGISLPPNMQGLTDDQIVELKLKDEWEERCIPSGGAEFKKDEIGRRNGHAPNEKMKDVLRRTMEEAKALISKKQLQANVCVTMEMVKEALDQLRGAVMIVYPMGLPPHDPIRMEIENQEDLTGTQASLQVITNEEAQLWWASKELHRGKKLQDYIGKNEKTKIIVKIQKRGQGAPAREPVVSEDEQKQMMLHYYKRQEELKKLEEADDDTHLQSEWSDRQALKRQFQGLTNIKWGPR