Protein
Centrosomal protein of 63 kDa-B
Function
Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication. Plays a role in DNA damage response: following DNA double strand breaks (DSBs), it is delocalized from centrosomes due to phosphorylation by atm and atr, leading to inactivate spindle assembly and delay mitotic progression (By similarity).
Similarity
Belongs to the CEP63 family.
Sequence
MEALLQGLQRQDRMGALQDSCEAELQELMKQIDIMLDHKRSQWEAETETMKTRLELKEQELNCALDSEERLNQEVRRLRQQLIQQEEETQNKTTQYEAQLSGFKEELNRLKKSYEKVQKKHLRSEMKAKAEEERSEVSRLTRRLEEFRQRSLDWEKQRLLYQQQLSGLEAQRKTLIEQTEMYQQQSHNRKQMLEQTNLVGRSELQNLSGQLHRANDSLCAKEEELETLKIQLRCAVEGQKRAEHETELSKQAVQALKEKAELRATLQAHTEFLQGSRVQKHELLPEGYRGSEVLRENNSIRSLEERLQETGQVGGETEVEAIRSKLSVSRMNEQRLQAEVTCLEDSVESVTSQCQLLAKELKGKEEYLHGVKEDHQKCLSENKKLKGQLSQAELTHKSVLDGMRKEISQLTQELHQRDIRMASSAGIDWERKIKAERQRAEREAAEHRMSLNALENLRQENCRLSELLQTQEPDVAQALVNLEQANQRLQRELLQTQEKLELIAQRRESEIQNAVDSISQELLNKQEQELRIMQERLKVYEQEMQTFRSQQDAASSGSSLESIFSEVWKEQATGSPISAASVDSAIEPVEDLASSLPVPPTSPANAVASRFLQEEEQRSHELLQRLNAHIEELKQESQRTVEHFTQAR