ceo

N(5)-(carboxyethyl)ornithine synthase

317 amino acids

Catalyzes the NADPH-dependent reductive condensation between pyruvic acid and the side chain amino group of L-ornithine to form N(5)-(L-1-carboxyethyl)-L-ornithine. To a lesser extent, can also use L-lysine as substrate (yielding N(6)-(L-1-carboxyethyl)-L-lysine), and the D-isomers of the 2 basic amino acids. Can use alpha-keto acids other than pyruvate, e.g. glyoxylate.

Belongs to the AlaDH/PNT family. CEOS subfamily.

35.849 kDa

MKLGFLIPNHPNEKRVALLPEHVKGFNNELVIETGFGETLGISDAEYVKVGCTIASREEIFKTCEGIFSLKVLKPQDYKHIREGQIIVGWTHPEGSGKIFMEEQGIPKNLIIVDLDNIHPSIYYKDYVIPMEWIPSNFVRKNSYIAGYASTMHAVMNYGSIPTSETKVAILGSGNVSQGAFSAISKFNPDIRMFYRKTMNQLKDELEEFDIIINGIEMDNPNKHILTLEDQMRLKKNCLIIDAAANLGKAIEGARHTTASDPIYNKDGKYYYAVNNSPSIFYRQSSKAISEAFSKHVYSKELEFYLDVIAEVEEMIV

ceo

N(5)-(carboxyethyl)ornithine synthase

313 amino acids

Catalyzes the NADPH-dependent reductive condensation between pyruvic acid and the side chain amino group of L-ornithine to form N(5)-(L-1-carboxyethyl)-L-ornithine. To a lesser extent, can also use L-lysine as substrate (yielding N(6)-(L-1-carboxyethyl)-L-lysine). NADH cannot replace NADPH in the condensation reaction.

Belongs to the AlaDH/PNT family. CEOS subfamily.

35.323 kDa

MKIGLVKANFPGERRVPLLPKDIKDFKNEILVEEGFGKFLDIDDQEYSDKGCHILSRAEVFAESEAIFSLKLIQPTDYYHLREGQMIIGWTHPFGSGQSFMKEQALPKKLIVVDLDSNSPCIYYENEIFESGIPKGLLYKNSFYAGYAGVLDALLQYGLIPTEETKIAILGSGNVAQGAFSSISKYSSNIRMYYRKTMSIFKENYTKYDIIINGIEIGKDDDPILSFSEQKSLKKGTLIIDVAADAGNTIEGSHFTSIDAPIYENAGKYYYVVPNTPSLIYRNVSQELSKILSENIFRKDCSRFIEKVKPLNK

ceo

N(5)-(carboxyethyl)ornithine synthase

309 amino acids

Catalyzes the NADPH-dependent reductive condensation between pyruvic acid and the side chain amino group of L-ornithine to form N(5)-(L-1-carboxyethyl)-L-ornithine. To a lesser extent, can also use L-lysine as substrate (yielding N(6)-(L-1-carboxyethyl)-L-lysine) (By similarity).

Belongs to the AlaDH/PNT family. CEOS subfamily.

35.008 kDa

MKIGLVKTNFPGERRVPLLPKDIKDFKNEILVEEGFGKFLDIDDQEYIDKGCHILSRAEVFSESEAIFSLKLIQPTDYPYLREGQMIIGWTHPFGSGRLFMKEQALPKKLIVVDLDSNSPCIYYENEIFESGIPKGLLYKNSFYAGYAGVLDALLQYGFIPTEETKIAILGSGNVAQGAFSSISKYSSNIRMYYRKTMSIFKENYTKYDIIINGIEIGKEDDPILSFSEQKSLKKGTFIIDVAADAGNTIEGTHFTSMDDPIYENDGKYYYVVPNTPSLIYRNVSQDLSKILSENIFSEDCSRFLSIKS