ced-8

Gene

ced-8

Protein

Cell death abnormality protein 8

Organism

Caenorhabditis briggsae

Length

460 amino acids

Function

Acts downstream of ced-9 and caspase ced-3 to promote phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Regulates apoptosis kinetics during embryonic development. Not required for engulfment of germ cell corpses.

Similarity

Belongs to the XK family.

Mass

53.816 kDa

Sequence

MYLKKHESKLLLIPKNEDKEDAGIIAVLTDRVPSVLIVRWFDLFCFGFAMCSYVLDFFSDIGIAIFHFWAGRHLSGALVLTFALIPSVIINIISMVWMLDDEMHWKRRAHPRRTGTFELNQKRFISLGKMITLCIFQMGPLFWYYKALYYGWMFTKNKKDDTDKEKRKFFMKMVEAERDATLLRFFEAFLESAPQLIIQGSIAANYFQNYYISGKYPYWLYFQAASLTLSIISISWSVVVQNRSLRMTRDDKVNIWPHEAVLQFCWRFLTILARIITLVAFVLLFGIYVVFLIFGHLIVTLVHVIFLQALHIEACTHIEKLLLLINAMIHLFTPFNMAEGNTRYRYLVAYTVEFIEMMIIFLLLPTPLDAFPLIEKIRIGVPATFFIGIFIMLIYYKFFHPNRRQDLEAPNVERNEKLVVSELNGIPSAAIEKAEHIEEIEEHSVPTTSESLLEEDECHN

Protein

Cell death abnormality protein 8: ced-8

Gene

ced-8

Protein

Cell death abnormality protein 8

Organism

Caenorhabditis elegans

Length

458 amino acids

Function

Acts downstream of ced-9 and caspase ced-3 to promote phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling (PubMed:24225442, PubMed:23845944). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:24225442, PubMed:23845944). Regulates apoptosis kinetics during embryonic development (PubMed:10882128, PubMed:1936965, PubMed:24225442, PubMed:23845944). Not required for engulfment of germ cell corpses (PubMed:9927601).

Similarity

Belongs to the XK family.

Mass

53.273 kDa

Sequence

MFLKKHKSKLLLVPRDEEQEDAGIVAVLTDRIPSVLLVRWFDLFCFGFAMCSYALDFFSDIGIAIFHFWAGRYLSGSLVLAFALLPSVIINIISMVWMLDDEMHWKRRAHPRRTGTFELNQKRFIPLSKMIVLCICQMGPLFWYYKALYYGWMFRKSSNENTDGEKRKCFSKMVEAERDATLLRFFEAFLESAPQLIIQGSIAASYFQNYYQTGTYPYWLYFQAASLLLSIISISWSVVVQNRSLRMIRDDKVNIWPHEAVLQFCWRFLTILARIITLVALVLIFGINVVPLISVHLLVTLVHVIFLQAIHIDACTHIEKLLLLINTFIHIFIPFNMVEGNTRWRYLTAYSVEFIEMMLVCWLLPLSLNTFPYIEKVQVGVPISFIAGIAIMMMYYQFFHPNRRQLIVTQSQEDLSLNVQKSVETLTPKLESSLEISGEQNTSQDLVSELLLDVEHEN

Protein

Cell death abnormality protein 8: ced-8