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cdt1

Gene
cdt1
Protein
DNA replication factor Cdt1
Organism
Xenopus laevis
Length
617 amino acids
Function
DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with cdc6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication.
Similarity
Belongs to the Cdt1 family.
Mass
69.536 kDa
Sequence
MSQMRVTDFFSQSKRGTAAQNSKGRKVEAVLETRRAVTRSRAASVKAEEFLKAPCTPERASPTVSQCIGPSSKKRTRQDSDSEPLRTQQRQGKSARKKLKLPEGEHGGSVQQQLFSPCNKVALEHVTPSSLGKKIKDMVNVSLSPKFNELARNPTTPETKSPAKENLLELKSRLQRIQELAQKVNLPAASSEGKVTITDLKARLKRAQELDTKIRAKAEKTETQAIDLTEQPAQESEKAPAYQRFHNLAQDAAPGLTLPYKYKVLAEMFRSMDTIVGMLFNRSETITFSKVKQGVQDMMRKQFEQRNVGQIKTVYPNAYKYRQEKNIPTFKDGVKKTDYQLTIEPLVAEGDMLSGRPHLSASRLLERKQLFHRSLTSIVKQHHRVFLTSLNPPMLVPDDKLTRWHPRFNVDEVLDVTPAELPLPPQVERLTTAQEVLSKARGLITPKMEKALANLALKTAENAGETKNVSTEETKSTATTSTSTALKGVSQSLLERIRAKEAQKLQAIMTRRPQQEERLLMMSRLPELARILRNVFVAEKKPALTLEVTCSRVIASCRSSMSPGEMEKHLALLSEILPDWLSIHPVRKDTYYKLNQSMDLNLILERLAKKTKEEESL

Gene
Cdt1
Protein
DNA replication factor Cdt1
Organism
Mus musculus
Length
557 amino acids
Function
Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC). Required also for mitosis by promoting stable kinetochore-microtubule attachments (By similarity). Potential oncogene (PubMed:11850834).
Similarity
Belongs to the Cdt1 family.
Mass
61.51 kDa
Sequence
MAQSRVTDFYACRRPGLTTPRAKSICLTPSPGGLVAPAFTRSSSRKRARPPAEPGSDQPAPLARRRLRLPGLDSCPSSLPEPSSPAEPSPPADPSPPADPGSPVCPSPVKRTKSTTVYVGQQPGKIPSEDSVSELQSCLRRARKLGAQARALRARVQENAVEPSTPDAKVPTEQPCVEKAPAYQRFHALAQPGLPGLVLPYKYQVLVEMFRSMDTIVSMLHNRSETVTFAKVKQGVQEMMRKRFEERNVGQIKTVYPTSYRFRQECNVPTFKDSIKRSDYQLTIEPLLGQEAGGATQLTATCLLQRRQVFRQNLVERVKEQHKVFLASLNPPMAVPDDQLTRWHPRFNVDEVPDIEPAELPQPPVTEKLTTAQEVLARARSLMTPKMEKALSNLALRSAEPGSPGTSTPPLPATPPATPPAASPSALKGVSQALLERIRAKEVQKQLARMTRCPEQELRLQRLERLPELARVLRNVFVSERKPALTMEVVCARMVDSCQTALSPGEMEKHLVLLAELLPDWLSLHRIRTDTYVKLDKAVDLAGLTARLAHHVHAEGL

Gene
CDT1
Protein
DNA replication factor Cdt1
Organism
Homo sapiens
Length
546 amino acids
Function
Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity).
Similarity
Belongs to the Cdt1 family.
Mass
60.39 kDa
Sequence
MEQRRVTDFFARRRPGPPRIAPPKLACRTPSPARPALRAPASATSGSRKRARPPAAPGRDQARPPARRRLRLSVDEVSSPSTPEAPDIPACPSPGQKIKKSTPAAGQPPHLTSAQDQDTISELASCLQRARELGARVRALKASAQDAGESCTPEAEGRPEEPCGEKAPAYQRFHALAQPGLPGLVLPYKYQVLAEMFRSMDTIVGMLHNRSETPTFAKVQRGVQDMMRRRFEECNVGQIKTVYPASYRFRQERSVPTFKDGTRRSDYQLTIEPLLEQEADGAAPQLTASRLLQRRQIFSQKLVEHVKEHHKAFLASLSPAMVVPEDQLTRWHPRFNVDEVPDIEPAALPQPPATEKLTTAQEVLARARNLISPRMEKALSQLALRSAAPSSPGSPRPALPATPPATPPAASPSALKGVSQDLLERIRAKEAQKQLAQMTRCPEQEQRLQRLERLPELARVLRSVFVSERKPALSMEVACARMVGSCCTIMSPGEMEKHLLLLSELLPDWLSLHRIRTDTYVKLDKAADLAHITARLAHQTRAEEGL

Gene
cdt1
Protein
Cell division cycle protein cdt1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
444 amino acids
Function
DNA replication licensing factor, required for pre-replication complex assembly. Faithful duplication of the genetic material requires 'once per cell cycle' DNA replication initiation and elongation. Central to this control is the tightly regulated formation of prereplicative complexes (preRCs) at future origins of DNA replication. Required for the recruitment of the MCM helicase complex to the replication origins.
Similarity
Belongs to the Cdt1 family.
Mass
49.956 kDa
Sequence
MKCRALYSHDNNILIFGFCVQIMSAGSQTKLNFSVRKTRSSSKRSNAAIIEPPKNPEDSQIIPAVKRLKENLDTESLEQNEVLPPVKNESVLFLEKVFNAVDICVKFHLSINTKPTFVLLENKVSGLTKISLKITHLAQILTVWPESFAITPCFTIHQGKRVATYELSYPRNANLPEAFSRSIEFKRRLEKWLLEHCSETEIPAQQLQALPSLSKNTVNESSLVRKLNLEKSTSRELRIPTQTLEPKFTTNTAKYANELVSCSMLDSSSTLSKSVNSKINLKSHQSSSSVQNSSRKLTSSQLTLRQSSLFDRVRKKQKAMEAKKAEEFKNNLVVHTLAKEKVSFVRIIDLIFVQLSTWPTKRSFSMSEIVTSMQMSISSSLSPDQCAKAIELLSKALPAWCTINLLGNIQVVTFSRIVNGKPYLRSQLIEELQTKASITILSNS