Protein
Cyclin-dependent kinase 8
Organism
Caenorhabditis briggsae
Function
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Sequence
MIDENFKKKLAVSRERVEDLFYFENSKEIGRGTYGLVYKAVPKHSNGRFPNKEYALKMIEGQGFSMSACREIALFRELRHPNLICLQRVFLTNEKKVWLLLDYAEHDLWHVIKHHRTAKTKKVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGGPDMRGRVKIADLGFSRIFANPLKPMAELDPVVVTFWYRAPELLLGAKHYTKAIDVWAIGCIFAELLTAEPLFFCKEEDIKAQNPYHYDQVKRIFHLLGYPSDTDWPDMKKMPDHQRLLNDARNEGTPIQTFPNSLQRYFDKWKINSQSSPYRLLVKLLTVDPLKRVSCEEAMNDIYFRKMERPPRETDDVFNRYPIPYAKKEQQITIPIDQFQQQQQQQQQQQQQQQQQQQQQQQQQMQQPQIGPPQMMGQPQMGQPQMGQPQMGQPQMGQPQMGQPQMVPSQMGQPPMGGPHPGVVAPDGHAHQMMQQQHQSQHHMQYQQMHDSMQGGMDDGGPQAKMMRMGNVPVGRYGPMGPPYGPQDFHAPQGPPMMQMMPQPGPSGYYQQRPGQPPGPGPQGYMNPQMGMTMGMRPQGVPQQAYMPGRGMPPPQGPNPQQQQQWQQYHR