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cdiI

Gene
cdiI
Protein
Immunity protein CdiI-YPIII
Organism
Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
Length
177 amino acids
Function
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Neutralizes the toxic activity of cognate toxin CdiA-YPIII (residues 954-1077). Does not inhibit toxic activity of CdiA from other toxin-immunity modules.
Mass
19.925 kDa
Sequence
MNDIVKSAWASVKMNTDFICVDTYSGYRSNQLDPLGVQHLSSPDVSDLDLGEMVKDALSHSRFVLPAPRTDIWIHPEVTFDLDLYDSRRTVERYDEWVKKLMVHYGYKTKRALFKDMKSCDICCNHDAITISPTRHEKLEVWGGTGLKGSDNVILSVDSSPTEIGAGLRLALSRCKG

Gene
cdiI
Protein
Immunity protein CdiI
Organism
Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56)
Length
145 amino acids
Function
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Protects cells against the 16S rRNase activity of CdiA-CT, its cognate toxin protein, but not against the toxic effects of a similar rRNase, non-cognate CdiA-CT from E.chrysanthemi strain EC16.
Mass
16.867 kDa
Sequence
MFGIFSKGEPVSMEGELVQPSSIVINDYEEELHLPLSYWDIKDYKNSWLKSLGEGLSNKTHSALAVSMYEPEKTNFIFTWVLYFEDEKVYVQNNVIFLEECHGFSPENINKFIESRTTHDGDGMKISEWHTDLNSVLDFYHSLNN

Gene
cdiI
Protein
Immunity protein CdiI
Organism
Dickeya dadantii (strain 3937)
Length
143 amino acids
Function
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Protects cells against the DNase activity of CdiA, its cognate toxin protein, but not against non-cognate CdiA from E.coli strain 536 / UPEC.
Mass
16.195 kDa
Sequence
MLAWNNLVEMLGCSKASNEFIYLPQKLNELPVFEEGVLGDRSYYSFFNSGVLFLLEDDLVNQISLYIQADEGFSAYTGELPLPVNSRESEIIQVLGTPSGSGGGKMDMLLGYVNRWIKYKTESHTLHIQFDQNDQLCRVTLMQ

Gene
cdiI
Protein
Immunity protein CdiI
Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Length
128 amino acids
Function
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Protects cells against the tRNA nuclease activity of CdiA, its cognate toxin protein, but not against CdiA from E.coli strain EC93 or D.dadantii strain 3937. Binding to CdiA-CT in the CdiA-CysK complex probably blocks the tRNA-binding site of CdiA-CT (PubMed:27531961).
Mass
14.817 kDa
Sequence
MITLRKLIGNINMTKEPEQQSPLELWFERIIDVPLEKLTVEDLCRAIRQNLCIDQLMPRVLEVLTKEPLAGEYYDGELIAALSTIKGEDLKDQKSTFTQIRQLINQLEPSDINDDLRKDILKINQIIV

Gene
cdiI
Protein
Immunity protein CdiI
Organism
Escherichia coli (strain STEC_O31)
Length
121 amino acids
Function
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Protects cells against the tRNA endonuclease activity of cognate toxin CdiA-STECO31 but not other non-cognate toxins, inhibits the tRNase activity of the isolated CT fragment of CdiA-STECO31. Binds the CT fragment of CdiA-STECO31, between two subdomains.
Mass
14.347 kDa
Sequence
MNKYLFELPYERSEPGWTIRSYFDLMYNENRFLDAVENIVNKESYILDGIYCNFPDMNSYDESEHFEGVEFAVGYPPDEDDIVIVSEETCFEYVRLACEKYLQLHPEDTEKVNKLLSKIPS

Gene
cdiI
Protein
Immunity protein CdiI
Organism
Yersinia mollaretii (strain ATCC 43969 / DSM 18520 / CIP 103324 / CNY 7263 / WAIP 204)
Length
121 amino acids
Function
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Protects cells against the tRNA endonuclease activity of cognate toxin CdiA-43969 but not other non-cognate toxins, inhibits the tRNase activity of the isolated CT fragment of CdiA-43969.
Mass
13.927 kDa
Sequence
MKKELFSQQDIDDGLDLIIVSYFDRMYGDGKFLDAIDLLSRKWTLNVDGAYCHFPDMNSYDESEHFDGVEFAIGYPPSDAESVIVSEDICYQYVRLACEKYLKLHPEDAEKVKDLLTKLPA

Gene
cdiI
Protein
Immunity protein CdiI
Organism
Burkholderia pseudomallei
Length
109 amino acids
Function
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Neutralizes the toxic activity of cognate toxin CdiA (C-terminal 282 residue CT fragment) upon expression in E.coli. Does not inhibit toxic activity of CdiA from other strains of B.pseudomallei.
Mass
11.891 kDa
Sequence
MNIDLQRRYDSSDDFFSLGGSVVMKLSADAAIAVCERAGQHGLVVARIEGGIWHFPGFEARLDCIWDGIDPPVDVGVAEQNNLAAAEFVRSESQEHDVFVVTAPEITGW

Gene
cdiI
Protein
Immunity protein CdiI
Organism
Burkholderia pseudomallei
Length
109 amino acids
Function
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Neutralizes the toxic activity of cognate toxin CdiA (C-terminal 160 residue CT fragment) upon expression in E.coli. Does not inhibit toxic activity of CdiA from other strains of B.pseudomallei.
Mass
12.139 kDa
Sequence
MAGSIVISKEVRVPVSTSQFDYLVSRIGDQFHSSDMWIKDEVYLPMEEGGMSFISTESLNSSGLSIFLATVMRARAASQAEESFPLYENVWNQLVEKLRQDARLGVSGN

Gene
cdiI
Protein
Immunity protein CdiI
Organism
Escherichia coli (strain NC101)
Length
106 amino acids
Function
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Neutralizes the toxic activity of cognate toxin CdiA-NC101 (the C-terminal 154 residue CT fragment) (PubMed:26305955). Does not inhibit toxic activity of CdiA from other toxin-immunity modules or strains of E.coli (Probable). Mediates dimerization of the ternary CdiA-CT-NC101, CdiI-NC101 and EF-Tu complex; both CdiI molecules contact both EF-Tu molecules (PubMed:28973472).
Mass
13.065 kDa
Sequence
MDIWPEFQRDLEMYRDVVLSIKRNLRLYEECIESLVHQIGSTNFDNAQPLFDDLFRMQSELATMLYKYEYKPGKRIQDLIYHLDRDDFYSRKYWHKKFSDGLAWPE

Gene
cdiI
Protein
Immunity protein CdiI
Organism
Escherichia coli
Length
79 amino acids
Function
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Protects cells against CdiA from the same strain, its cognate toxin protein (PubMed:16109881, PubMed:23882017). Growth inhibition is reversible upon induction of this protein, occurring about 2.5 hours after induction, and requires an energy source (PubMed:19124575). Does not protect against non-cognate CdiA from E.coli strain 563 / UPEC, D.dadantii strain 3937 or Y.pestis strain CO92 (PubMed:21085179).
Mass
8.856 kDa
Sequence
MKKKLFALLKYIIFFPMLCTVLGLLGIPIGLIVNFLRTGSFDFNLKDEIDVVLFTLKIGIPIGFILGLGLWGLSILDRK

Gene
cdiI
Protein
Immunity protein CdiI
Organism
Yersinia pestis
Length
77 amino acids
Function
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Protects cells against the CDI activity of CdiA, its cognate toxin protein, but not against non-cognate CdiA from E.coli strains 563, EC93 or D.dadantii strain 3937.
Mass
8.719 kDa
Sequence
MKNLLYVVLLMAVCILGLLIVGTIFYLFLEVFMYFYVNAPISLESFQFTRLLKMSIYGGGILGLGIGLLRIFKIKGF