cdc6-3

ORC1-type DNA replication protein 3

394 amino acids

Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds to DNA, with a preference for molecules that contain a bubble, a fork, or a tail. Inhibits the binding of the MCM helicase to the origin DNA and inhibits its DNA helicase activity. Also regulates the DNA polymerase and the nuclease activities of PolB1. Inhibits the DNA-binding activity of Cdc6-1 and Cdc6-2.

Belongs to the CDC6/cdc18 family.

44.554 kDa

MHVIRETLKGGKGEVIKNPKVFIDPLSVFKEIPFREDILRDAAIAIRYFVKNEVKFSNLFLGLTGTGKTFVSKYIFNEIEEVKKEDEEYKDVKQAYVNCREVGGTPQAVLSSLAGKLTGFSVPKHGINLGEYIDKIKNGTRNIRAIIYLDEVDTLVKRRGGDIVLYQLLRSDANISVIMISNDINVRDYMEPRVLSSLGPSVIFKPYDAEQLKFILSKYAEYGLIKGTYDDEILSYIAAISAKEHGDARKAVNLLFRAAQLASGGGIIRKEHVDKAIVDYEQERLIEAVKALPFHYKLALRSLIESEDVMSAHKMYTDLCNKFKQKPLSYRRFSDIISELDMFGIVKIRIINRGRAGGVKKYALVEDKEKVLRALNETFEDSISIGDFDDVGEN

cdc6-3

ORC1-type DNA replication protein 3

386 amino acids

Involved in regulation of DNA replication.

Belongs to the CDC6/cdc18 family.

43.667 kDa

MAIRETLKGGKGEVIKNPKVFIDPLTVFKDIPFREDILREVAIAVRYFVKNNMKFSTLFLGLTGTGKTFVAMYMFNEIQEVKKEDGEYGVVSQAYVNCREVGGTPQAVLSAITQRITGEEVPKHGINLGEYIERIKENLVDKKALIYLDEVDTLIKRRGGDIVLYQLLRANADISVIMVSNDINIRDYMEPRVLSSLGPTIFFKPYDAEQLKHILSIYSEYGLIKGSYTDEILSYIAAISAKEHGDARKAVNLLFRAAQLASGEGMIRKEHVDRAIIEYEQERLIEAIKALPFHYKLALIASMQASDVITAHKIYSDLCNEYKQKPLSYRRFSDVISELDMFGIIKVKIINKGRAGGIKKTIEVADKEKITKALEEAMQLEYEDTV

cdc6-3

ORC1-type DNA replication protein 3

386 amino acids

Involved in regulation of DNA replication.

Belongs to the CDC6/cdc18 family.

44.022 kDa

MSIRDTLKGGKGEVIKDPRVFIDPLTVFKDIPFREDILKEVAVAVRYFVKSDVKFSTLFLGLTGTGKTFVARYMLNEIEEVKQEDSDYSKVKQAYVNCREVGGTPQAVLSALTERLTTDEVPKHGINLGEYIEKIKEELNGKKALVYLDEVDTLIKRRGGDIVLYQLLRADADISVIMISNDINIRDYMEPRVLSSLGPTVFFKPYDAEQLKHILSIYAEYGLYRGTYDDNILSYIAAISAKEHGDARKAVNLLFRAAQLASGEGFIRKDHVDRAIIEYEQERLIEAIKALPFHYKLALMATMDAEDVVTAHKIYSDLCNQYKQKPLSYRRFSDIISELDMFGIIKVKIINKGRAGGIRKYIEITDKDKIRKALEDTMNLGFEEQW