cdc6-2

ORC1-type DNA replication protein 2

418 amino acids

Involved in regulation of DNA replication.

Belongs to the CDC6/cdc18 family.

47.845 kDa

MKVLDELRDLVEDAIKGSTVFEKSKVLTPDYIPKNLPHREKQIKELSINFREILSNPGSTSVRVVISGKTGTGKTVTTKKFGELFSEIAKEKGLRVVYTHINCHRQRTLYLMLVEIANQLNLQIPNRGLSSQETFKLIYDYLEKRNIQLIITLDEFDYFVSTSPVEDIYFLVRIYDELNALVKRIHYIFILRELTSLASLDKSIKDHVIKNVIEFPPYTSEELYDILMDRIVNEKAFREGAVLEETVRFISDIYGIDKGGSGNARLALETLELAGKIADTEGSLLVTIDHAKKANSKINPELSIILDTIRDLDLHQLLVVKAIMNLHKKEGDDFFSMGKVEEEYNIVAKDLGEIPRKHTQVFEYIRKLKLMGLITARQSGKGMRGRTTLISLSVPISEELDNLINNEIRDRLLQQKNY

cdc6-2

ORC1-type DNA replication protein 2

415 amino acids

Involved in regulation of DNA replication.

Belongs to the CDC6/cdc18 family.

47.924 kDa

MDDIKNLIEDLLGGDTVFNNTKILNPEYIPSNLPHRENQIKEMTVSFRDLILNPGSSSIRLVIIGRTGTGKSVTTKKFGLKLREIAHERNLRLEYVHVNCHRQRTLYLILQEISQGLRLQLPNRGLSSQETFRIIYDYLEKRNIHLVITLDEFDYFVSTAPLEDIYFLVRVYDELNVTTKRLHYIFIVREITSLSGLDKSIKDHIIKNIIDFPPYKSTELYDILADRVYNEKAFKENSVSEDVLRFIAEVHGFDKGGSGNARISIETLELAGKIADSENSPIVTLEHAKKANSKINPELSALIDSIKELDLHQLIFLKALVLLHDQEGIDFFPIGKIEQRYVELSKNFGEEPRRHTQIFEYVRRMKLMGLINTRQSGRGMRGRTTLVSLPIPISMEFKDLINTEIRKRLEQSRIS

cdc6-2

ORC1-type DNA replication protein 2

413 amino acids

Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds both single-stranded and double-stranded DNA, with a preference for molecules that contain a bubble, a fork, or a tail. Has a weak ATPase activity. Stimulates the binding of the MCM helicase to the origin DNA, but strongly inhibits ATPase and DNA helicase activities of MCM. Also regulates the DNA polymerase and the nuclease activities of PolB1.

Belongs to the CDC6/cdc18 family.

47.533 kDa

MVSAKDILSDSLRSSVLIIKHKDKLSPDYVPENLPHREEKIKELGFIFKDLLAGDAKDSERVVILGRTGTGKTATVRLFGKNFEDIAEREYGVKVKYVHINCYRHRTLYLISQEIANALKLPIPSRGLSAQEVFKMIHEYLDRRNIHLIVALDEFGHFLNTANTEEIYFLVRLYDEISAIIKRISYIFIVNESHSIYKLDRSIRDHIARRLIEFPPYKSMELYDILKYRVDEAFNDNAVDDEVLQFISNTYGYDKGGNGNARIAIETLSLAGEIAEKEGSPVVLLDHAKKANSTINPEIQEIIDSLSYLDLHQLILLKALIRALNKTKADEITMGTLEEEYISLSREFNEEPRRHTQVYEYLRKLKVIGIINTRQSGKGMRGRTTLVSLSLPLDKRLDDYIMQQIMVRLKSRA

cdc6-2

ORC1-type DNA replication protein 2

404 amino acids

Involved in regulation of DNA replication. Stimulates the helicase activity of MCM via stimulation of its ATPase activity. Binding to MCM may result in conformational changes in MCM, leading to catalytic ATP hydrolysis by the helicase. Directly stimulates MCM movement along single-stranded and double-stranded DNA. Does not bind DNA.

Belongs to the CDC6/cdc18 family.

45.639 kDa

MDNPFARFAGTRTIQANLSLLEENYVPDSFPHRENQINEMVTILSSIMRGSRPSNIIVYGKTGTGKTSTTKYVTKMLVEAASNVSVVYVNCEIYDSPYSILVAIANSAGEEKIPELGWPIDRIYRETVERVEKTGKFFIIILDEMDRLIKKNGGDSLYVLLKLMTDVDSVRVSMIGITNDTTVLENIDARIKSRLNQESIVFPPYNASEIRDIISSRLDKVLGPGVVDDTAINLCAAIGAQEHGDARKAIDLMRIAIEIAIRENRNKITENEIYEARERYEMNVLREAISTLPLHSKIVLLSAVVTQEIEPNSVITGEIYENYRRICDDLGFSPLSPRRISDLLTELADYGLLVMDDRNMGKYGRTRSFSVVHQAETIKKYLLEDENLSMFKSSKMPKQTRFDT

cdc6-2

ORC1-type DNA replication protein 2

379 amino acids

Involved in regulation of DNA replication. Dissociates the MCM complex and inhibits the MCM helicase activity, suggesting that it may function as a helicase loader. Binds to both specific and random double-stranded or single-stranded DNA.

Belongs to the CDC6/cdc18 family.

43.302 kDa

MKGDKRRDIRDILLHDETLFRNMNAFDPDYVPENYRYRESQMEALAVCIRPALRNGRPVNAVILGSCATGKTTAIKKIFEMVESTSEGVVCCYINCQLHTTRFGIFSQIYSKIFGHQPPETGVPFSRIYQTIMQHLASEKRALVVALDDINHLFYSKNANKVLYDILRAHEVFEGVRTGVFAVLSDIEFRYALDKNVDSIFIPQEIVFPPYTREEVFNILRDRVRVGFYPGVISDELLERITDHTMDTGDLRYGIDLLRVCGNLAEADASPVIGEEHLERALKSTGPVNLIHTVRTLNENEREFLRILADAGEDMTAGALYELFRESTGSSYSSFNRIIEKLEFLRLIDTRLTGKGVRGNSRILIPRFSREDLRRCPGF

cdc6-2

ORC1-type DNA replication protein 2

376 amino acids

Involved in regulation of DNA replication.

Belongs to the CDC6/cdc18 family.

42.978 kDa

MQVKRIIHINVSFTLMLSWDETLFKNPEVFDPDYIPDELLFRDGQIRQLVSCIKPAMLNSSPINAFCLGPPSTGKTSTIRYVLREAERETGLLYSYIRIPRFKEPYKVFSKIFQDVLGQQSPPSGISKTVLMDRVWSNLDEPLLVVLDDINFLGKNYANEILYEILKAPDEYGVKVGIVAAATDVKFPLLLDPFVGASFHYMEIHYPSYGYAEIEGILRKRVEHGFYEGVFDDGAFRRVVELAYRASDVRYGIYLLKAAGMNAESRGSRKVEERDVEVAHAGESLSFIAKILTALNSEERAVLRMIYSQNAISTGDLYEQVCSEIKMSYRKYYNILEKLERLKLIEISFGEKGRGKTRYVQGKYDAEVVDRAMQLI

cdc6-2

ORC1-type DNA replication protein 2

373 amino acids

Involved in regulation of DNA replication.

Belongs to the CDC6/cdc18 family.

41.952 kDa

MTGNDILLWDETLFKDLSVLEPDYLPEYFPHRDSQLNALRFALRPSLRGMRPLNCLLVGPPGTGKTSAVMKVFREVEVHAPGVVAVKVNCQIDSTRFAVISRIYRQLFGISPPNSGIAFRKLFETVVNFLVSSEKVLIVALDDLNYLCCEGHANEVMYSLLRAHEQYPGAKIGVIGIVNDASDLYCLDSRVNSVFLPEEISFLRYGEAEILDILKDRVKYGFYPKVISDDVLELVVSYVEKTGDLRVGIDLLRRSGFNAERRGSRTISSGDVEKAYEASKLLHLCRGISLLSDSEKQLLELIAKADDVKAGELYKSFHELTQLGYTRFYGMVNRLQTLNYVDADFTGKGKRGRTRIIKAKYEAEDILNCLKKG

cdc6-2

ORC1-type DNA replication protein 2

373 amino acids

Involved in regulation of DNA replication.

Belongs to the CDC6/cdc18 family.

42.439 kDa

MTGNDILLWDETLFKDLSVLEPDYLPEYFPHRDSQLNALRFALKPALRGMRPLNCLLVGPPGTGKTSAIMKTFREVEAHAPNVVTVKVNCQIDSTRFAVMSRIYRQLFGISPPNSGIAFRKLFETVVNFLVSSEKVLIVALDDLNYLCCEGHANEVMYSLLRAHEQYPGAKIGVIGIVNDASDLYCLDSRVNSVFLPEEVSFPRYEEGEILDILKDRVRYGFYPKVISDEVLKLVVSYVEKTGDLRVGIDLLRRSGFNAERKGRRMILFEDVEKAYEASKLLHLCRGISLLSDPEKQLLELIAKKDEIKAGELYKSFHELTQLGYTRFYGMVNRLQTLNYVDADFTGKGKRGRTRIIKTKYEAEDILNCLKKA