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cdc28

Gene
cdc28
Protein
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein cdc28
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
1055 amino acids
Function
Involved in pre-mRNA splicing. Is required together with ATP and at least one other factor, for the first cleavage-ligation reaction. Functions as a molecular motor in the activation of the precatalytic spliceosome for the first transesterification reaction of pre-mRNA splicing by hydrolyzing ATP to cause the activation of the spliceosome without the occurrence of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.
Mass
121.217 kDa
Sequence
MSLEQYVSDKAISLLGMSEPSVVEYLIAEAKGSSSSNNLYQKLVSFGMDGDDPAVKEFAHTLYARIPREGSRPKENYNARKKKEQGILQMERLNSSYDLLIEPQSHETPGKPLKKKSRSKTPKREIARRQRDEDEWESDEYEEVVDGSASHPIEEDSVSTDFQNHDYEKSSDPETERLNDLREREEFEERLRRKDLEAATNEFVEDYSSKFSSEELALRKLADDPESWRKLASELRKKSRQQYLKPRAQQQLEILRREIRDEEQLFAGEKLTQAEIRELEKKKELLRIAEERQRLEKQATEYQMPEDYFTEQGKLDRKRKEEVLYQRYKDSNEGEQNEVTMGAAEQQRWEAQQINKALLFDQNEWLPPGEKQFDFVFDESQQIDFLLDTKLSAENPVDTDKMTDVKVEKSLESSRKSLPVYQYKDDLLKAINEYQVLLIVAETGSGKTTQLPQFLHEAGYTKGNKKICCTQPRRVAAMSVAARVAKEMDVRLGQEVGYSIRFENATSEKTVIKYLTDGMLLREFLTEPDLASYSVIIIDEAHERTLHTDILFGLVKDIARFRPDLKVLISSATIDAEKFSAYFDEAPVFYVPGRRYPVDIYYTPQPEANYIQAAITTILQIHTTQPAGDILVFLTGQDEIELMSENMQELCRILGKRIPEIILCPIYANLPSELQAKIFDPTPPGARKVVLATNIAETSITIDGVNFVIDSGFVKQNMYNPRTGMESLVSVPCSRASADQRAGRAGRVGPGKCFRLYTRRTYNNELDMVTSPEIQRTNLTNIVLLLKSLGINNLLDFDFMDAPPPETLMRSLELLYALGALNNRGELTKLGRQMAEFPTDPMLSKSLIASSKYGCVEEVLSIVSMLGEASSLFYRPKDKIMEADKARANFTQPGGDHLTLLHIWNEWVDTDFSYNWARENFLQYKSLCRARDVRDQLANLCERVEIELVTNSSESLDPIKKAITAGYFSNAARLDRSGDSYRTVKSNQTVYIHPSSSVAEKKPKVIIYFELVLTTKEYCRQITEIQPEWLLEISPHYFKPENIEELQKTQKRHKR

Gene
CDC28
Protein
Cyclin-dependent kinase 1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
317 amino acids
Function
Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and SEC2 upon induction of filamentous growth. The CDC28-HGC1 complex also phosphorylates SEC2 and maintains CDC11 phosphorylation throughout hyphal growth. Moreover, the CDC28-HGC1 complex phosphorylates and prevents RGA2 from localizing to hyphal tips, leading to localized CDC42 activation for hyphal extension. Finally, CDC28-HGC1 phosphorylation of EFG1 represses cell separation genes during hyphal growth. Additional substrates for CDC28 are RFA2 in G1-phase; MOB2, which is required for the maintenance of polarisome components and for inhibition of cell separation in hyphae; and GIN4 to regulate its association to SEP7 and subsequent septin ring assembly.
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Mass
36.647 kDa
Sequence
MVELSDYQRQEKVGEGTYGVVYKALDTKHNNRVVALKKIRLESEDEGVPSTAIREISLLKEMKDDNIVRLYDIIHSDSHKLYLVFEFLDLDLKKYMESIPQGVGLGANMIKRFMNQLIRGIKHCHSHRVLHRDLKPQNLLIDKEGNLKLADFGLARAFGVPLRAYTHEVVTLWYRAPEILLGGKQYSTGVDMWSVGCIFAEMCNRKPLFPGDSEIDEIFRIFRILGTPNEEIWPDVNYLPDFKSSFPQWKKKPLSEAVPSLDANGIDLLDQMLVYDPSRRISAKRALIHPYFNDNDDRDHNNYNEDNIGIDKHQNMQ

Gene
CDC28
Protein
Cyclin-dependent kinase 1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
298 amino acids
Function
This protein is essential for the completion of the start, the controlling event, in the cell cycle. More than 200 substrates have been identified.
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Mass
34.061 kDa
Sequence
MSGELANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLPDFKPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQES

Gene
CDC28
Protein
Cyclin-dependent kinase 1
Organism
Encephalitozoon cuniculi (strain GB-M1)
Length
296 amino acids
Function
Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis (By similarity).
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Mass
34.53 kDa
Sequence
MTESFQKLEKIGEGTYGVVYKARERNTNRVVALKKIRLENENEGIPATTIREILLLKNLKHSTIVELSDVIYNNNKMYLVFEYVELDLRRYLDRMSDEGRLVEEGFVRKMSQQLLTAMEYCHSRNIFHRDLKPQNILVDPKENIKLADFGLGRAAGIPLRTYTTEVVTLWYRPPELLLGCKYYDASVDVWSAACIMAEVVLMRPFFPGDSEIDQLFRIFKVLGTPNNSRWSNVENFPNYKVEFPVWDPVDLKTIFRGDPDFVDLISKMLEYDPKMRMTAKNGLSHKYFEGMPLIME