ccdc22

Coiled-coil domain-containing protein 22

639 amino acids

May be involved in regulation of NF-kappa-B signaling. May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery (By similarity).

Belongs to the CCDC22 family.

71.986 kDa

MEEVDRILIHSLRQAGTDIDEDVQSVKQFTSELIVEAVVRCLRVIDPAVGNGLSHSLPPGMSARFRLGMSLAQACQDVGFKGEIGYQTFLYSNEPEIRSLFMFLVERLPRESAEASDQPAGKSVLLQRAIAAQIKAQLSVPWLPPTCRLPVHRKTQSSGPCHSFHAQPLSLPCSLKVSSRKQPKEVQEYWRNYLLPVTAQPSQPASVPASLLENHISELSAAQEWESEWNSQGLLSRLTPEEYRSRKKARLQKRIEEQLRTAAQPRPDTHGATRSTSDLAELLQSFGGASTGGDVLTKGTRFTHTEKFTFTQEPEKAVQQMAAAASALPSSQQSEEDLKAQQEAELSALQQQLQQLSVQMEEVGGGIKQLTVSIQQVTDELQTREVTNAERENSVKIKRQTIDLLPDAENNLLKLQSLVESSSKRVVQLASQWEKHRVPLIDEHRRLKELCSNRESESSRKLSEIKDLHDKIRQSAEEAKKKESLYKQLLTEFETLSKDVSRSAYTIRILEIVGNIKKQKEEITKILSDTKDLQKEINGLTGKLDRTFAVTDELVFKDAKKDESVRKSYKYLAALHENCTQLIQTIEDTGTIMREIRDLEEQIETENGKRTVSNLEKILEDYKAIRQENSALAAKIREG

ccdc22

Coiled-coil domain-containing protein 22

632 amino acids

May be involved in regulation of NF-kappa-B signaling. May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery (By similarity).

Belongs to the CCDC22 family.

72.251 kDa

MEEVDRILIHSLRSCGTEVPEDIQSIRQFNTELIVEAVVRCLRVINPSLGATLSHVLPPGMSAQFRIGTSLAQACQDLGYSSEVGYQTFLYSSEPDIRALLIFLAEKLPRDSSEDAHQPAGKSALLQREIVATIKQQLSLPWLPLSCRIAALRRSQSSCRLHRFHSQPLSLASDPALKSIPNERKEYWQRYLPSVTSQLPHLPSVAASLLERNTSKLSAVQEWEAEWKSQGLASRLSPEDYRSKKQQRLQKRIQEQLRQCAQLLAENHLPSSSSQDLTDMLRAFNLDGGSDQKKGSRFTRTQRFTYQQDPHTLKEQMQRAAEILPKKDAQDADAEQQEISSLQEQIDSIEQEIRGLSESNKLLQLTIGQVEGEVNDMHQSCEEKANVVRVKKRAVELLPDADNNLDKLQTLVDASAQRMANLIGQWESHQARLSDEYMELNRVQQEQEDESSRWMKDAKDLYEKIQGSADEAKRKEELYKQLLSEYESLPKEVSRAAYTQRILEIVSNIKKQKEEITKILSDTKELQKEINNLTGKVDRTFVVTDELVFKDAKKDEPVRKAYKYLAALHENCSQLIQTIEDTGTILREIRDLEEQIETETTKKTLSNLQKILEDYRAIKQENAQLLARTREA

ccdc22

Coiled-coil domain-containing protein 22

632 amino acids

May be involved in regulation of NF-kappa-B signaling. May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery (By similarity).

Belongs to the CCDC22 family.

72.586 kDa

MEEVDRILIHSLRSCGTEVPEDVQSIRQFNTELIVEAVVRCLRVINPSLGATLSHVLPPGMSARFRIGTSLAQACQDLGYPGEVGYQTFLYSSEPDIRALLIFLAEKLPRDSPEDAHQPAGKSALLQREIAATIKRQLSLPWLPSSCRICALRRSQNSCRLHRFHAQPLSLATDPTLKSIPDERKEYWQCYLPSVTSQLPHLPSVAASLLERNTSELSAKQEWDAEWKSQGLASRLSPEDYRSRKRQRLQKRIQEQLRQCAQLLAENHLPSSSSQDLTDMLKAFNLDGGSDQKKGSRFTRTQRFTYQQDPHTLKEQMQRAAEILPKKDAQDTDAEQQELSSLQEQIDSIEQEIRGLSESNKRLQLTVSQVEGEVNEMRQSCEEKEKIVRVKKRAVELLPDADNNLVKLQALVDASSHRMANLVGQWESHQVRLSEEYRELKRVQQEQEDESSRWMKDAKDLYEKIRGAADEAKRKEELYKQLLSEYESLPKEVSRAAYTQRILEIVSNIKKQKEEITKILSDTKELQKEINNLTGKVDRTFVVTDELVFKDAKKDEPVRKAYKYLAALHENCSQLIQTIEDTGTILREIRDLEEQIETETTKKTLSNLQKILEDYRAIKQENAQLLARIREA

ccdc22

Coiled-coil domain-containing protein 22

632 amino acids

May be involved in regulation of NF-kappa-B signaling. May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery (By similarity).

Belongs to the CCDC22 family.

72.251 kDa

MEEVDRILIHSLRSCGTEVPEDIQSIRQFNTELIVEAVVRCLRVINPSLGATLSHVLPPGMSAQFRIGTSLAQACQDLGYSSEVGYQTFLYSSEPDIRALLIFLAEKLPRDSSEDAHQPAGKSALLQREIVATIKQQLSLPWLPLSCRIAALRRSQSSCRLHRFHSQPLSLASDPALKSIPNERKEYWQRYLPSVTSQLPHLPSVAASLLERNTSKLSAVQEWEAEWKSQGLASRLSPEDYRSKKQQRLQKRIQEQLRQCAQLLAENHLPSSSSQDLTDMLRAFNLDGGSDQKKGSRFTRTQRFTYQQDPHTLKEQMQRAAEILPKKDAQDADAEQQEISSLQEQIDSIEQEIRGLSESNKLLQLTIGQVEGEVNDMHQSCEEKANVVRVKKRAVELLPDADNNLDKLQTLVDASAQRMANLIGQWESHQARLSDEYMELNRVQQEQEDESSRWMKDAKDLYEKIQGSADEAKRKEELYKQLLSEYESLPKEVSRAAYTQRILEIVSNIKKQKEEITKILSDTKELQKEINNLTGKVDRTFVVTDELVFKDAKKDEPVRKAYKYLAALHENCSQLIQTIEDTGTILREIRDLEEQIETETTKKTLSNLQKILEDYRAIKQENAQLLARTREA

ccdc22

Coiled-coil domain-containing protein 22

632 amino acids

May be involved in regulation of NF-kappa-B signaling. May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery (By similarity).

Belongs to the CCDC22 family.

72.586 kDa

MEEVDRILIHSLRSCGTEVPEDVQSIRQFNTELIVEAVVRCLRVINPSLGATLSHVLPPGMSARFRIGTSLAQACQDLGYPGEVGYQTFLYSSEPDIRALLIFLAEKLPRDSPEDAHQPAGKSALLQREIAATIKRQLSLPWLPSSCRICALRRSQNSCRLHRFHAQPLSLATDPTLKSIPDERKEYWQCYLPSVTSQLPHLPSVAASLLERNTSELSAKQEWDAEWKSQGLASRLSPEDYRSRKRQRLQKRIQEQLRQCAQLLAENHLPSSSSQDLTDMLKAFNLDGGSDQKKGSRFTRTQRFTYQQDPHTLKEQMQRAAEILPKKDAQDTDAEQQELSSLQEQIDSIEQEIRGLSESNKRLQLTVSQVEGEVNEMRQSCEEKEKIVRVKKRAVELLPDADNNLVKLQALVDASSHRMANLVGQWESHQVRLSEEYRELKRVQQEQEDESSRWMKDAKDLYEKIRGAADEAKRKEELYKQLLSEYESLPKEVSRAAYTQRILEIVSNIKKQKEEITKILSDTKELQKEINNLTGKVDRTFVVTDELVFKDAKKDEPVRKAYKYLAALHENCSQLIQTIEDTGTILREIRDLEEQIETETTKKTLSNLQKILEDYRAIKQENAQLLARIREA

CCDC22

Coiled-coil domain-containing protein 22

627 amino acids

(Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface.

Belongs to the CCDC22 family.

70.756 kDa

MEEADRILIHSLRQAGTAVPPDVQTLRAFTTELVVEAVVRCLRVINPAVGSGLSPLLPLAMSARFRLAMSLAQACMDLGYPLELGYQNFLYPSEPDLRDLLLFLAERLPTDASEDADQPAGDSAILLRAIGSQIRDQLALPWVPPHLRTPKLQHLQGSALQKPFHASRLVVPELSSRGEPREFQASPLLLPVPTQVPQPVGRVASLLEHHALQLCQQTGRDRPGDEDWVHRTSRLPPQEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEKFTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENAGLLGRVREA

Ccdc22

Coiled-coil domain-containing protein 22

627 amino acids

Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes.

Belongs to the CCDC22 family.

70.844 kDa

MEEADRILIHSLRQAGTAVPPEVQTLRAFTTELVVEAVVRCLRVINPDVGSGLSHLLPPAMSARFRLAMSLAQACMDLGYPLELGYQNFLYPSEPDLRDLLLFLAERLPSDASEDADQPAGDSAIFLRAIGSQIRDQLALPWVPPLLRTPKVQRLQGSALQQPFHSSRLVLPELNSSGELWEFQASPLLLPAPTQVPQLQGRAASLLEHHASQLCQHVNRDCPGDEDRVRWASRVPSQEDSRAPQQRLHKQLIEHLRQSWGPLGAPTQVRDLGEMLQTWGARAMTGVPKGSRFTHSEKFTFHLEPQVQAAQVADVPATSQRLEQDTRAAQEQELESLREQLASVNHNIEEVEADMKTLGINLVQVETECRQSELSVAEQEQALRLKSRTVELLPDGAANLAKLQLVVESSAQRLIHLASQWEKHRVPLLAEYRHLRRLQDCRELESSRRLAEIQELHHSVRAAAEEARRKEEVYKQLVSELETLPKDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETEMGKKTLSNLEKICEDYRALRQENAGLLGRVREA

Ccdc22

Coiled-coil domain-containing protein 22

627 amino acids

Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes.

Belongs to the CCDC22 family.

70.855 kDa

MEEADRILIHSLRQAGTAVPPEVQTLRAFTTELVVEAVVRCLRVINPDVGSGLSHLLPPAMSARFRLAMSLAQACMDLGYPLELGYQNFLYPSEPDLRDLLLFLAERLPTDASEDADQPAGDSAIFLRAIGSQIRDQLALPWVPPLLRTPKVQRLQGSALQQAFHSSRLVLPELNCRGEPREFQASPLLLPAPSQVPQLLGRAASLLEHHAIQLCQHVNRDCPGDEDRVRWASRLPSQEDPRAPQQRLHKQLIEHLRQSWGPLGAPTQVRDLGEMLQAWGAKAMTGVPKGSRFTHSEKFTFHLEPQVQAAQVADIPAASQRPEQDTRAAQEEELESLREQLASVNHNIEEVEANMKSLGMNLVQVETECRQSELSVAEQEQALRLKSRTVELLPDGAANLTKLQLVVESSAQRLIHLASQWEKHRVPLLAEYRHLRKLQDCRELESSRRLVEIQELHQSVRAAAEEARRKEEVYKQLVSELETLPKDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETEMGKKTLSNLEKICEDYRALRQENAGLLGRVREV

CCDC22

Coiled-coil domain-containing protein 22

595 amino acids

Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes.

Belongs to the CCDC22 family.

67.042 kDa

MEEADRILIHSLRQAGTAVPPDVQTLRAFTTELVVEAVVRCLRVINPAVGSGLSPLLPLAMSARFRLAMSLAQACMDLGYPLELGYQNFLYPSEPDLRDLLLFLAERLPTDASEDADQSAGESAILLRAIGSRIRDHLALPWVPPLLRTPKLQYLQGSAHQKPFHASRLVMPELSSRGESREFQAGPLLLPVPAQVPQPAARAASLLEHHAIQLCQHTGRDRAGDEDWGHRTSRLPAQEDTRAQRQRLQKHLAEHLRQTWGRPGPPQQARDLGEVLQAWGAGARPGTPKGSRFTHSKKFTFHLEPEAQAAQVSDVPATSQRPEQDTWAAQEQELESLREQLEGVNHNIEEVEANMKTLGINLVQVETECRQSELSIVEREQALRLKSQAVELLPDGAANLAKLQLVVESSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLVSELETLPKDVSRLAYTQRILEIVGNIRKQKEEITKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETEMGKKTLSNLDKIREDYRALRQENAGLLGRVREA