casA

CRISPR system Cascade subunit CasA

502 amino acids

A component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity. Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target. This leads to the formation of an R-loop in which the crRNA binds the target DNA, displacing the noncomplementary strand. Cas3 is recruited to Cascade, probably via interactions with CasA, nicks target DNA and then unwinds and cleaves the target, leading to DNA degradation and invader neutralization. CasA is not required for formation of Cascade, but probably enhances binding to and subsequent recognition of both target dsDNA and ssDNA.

Belongs to the CRISPR associated protein CasA/Cse1 family. Type I-E/Ecoli subfamily.

55.901 kDa

MNLLIDNWIPVRPRNGGKVQIINLQSLYCSRDQWRLSLPRDDMELAALALLVCIGQIIAPAKDDVEFRHRIMNPLTEDEFQQLIAPWIDMFYLNHAEHPFMQTKGVKANDVTPMEKLLAGVSGATNCAFVNQPGQGEALCGGCTAIALFNQANQAPGFGGGFKSGLRGGTPVTTFVRGIDLRSTVLLNVLTLPRLQKQFPNESHTENQPTWIKPIKSNESIPASSIGFVRGLFWQPAHIELCDPIGIGKCSCCGQESNLRYTGFLKEKFTFTVNGLWPHPHSPCLVTVKKGEVEEKFLAFTTSAPSWTQISRVVVDKIIQNENGNRVAAVVNQFRNIAPQSPLELIMGGYRNNQASILERRHDVLMFNQGWQQYGNVINEIVTVGLGYKTALRKALYTFAEGFKNKDFKGAGVSVHETAERHFYRQSELLIPDVLANVNFSQADEVIADLRDKLHQLCEMLFNQSVAPYAHHPKLISTLALARATLYKHLRELKPQGGPSNG

casA

Metacaspase-1A

454 amino acids

Involved in cell death (apoptosis).

Belongs to the peptidase C14B family.

49.344 kDa

MSYGYPGQGYGPGGGHHQPPPPQWDGQQQHHHQGGYGYSNPGQGQYNPQPPQDQGYGGYHQQPPQQYQQGSYNQGQYPPQGGYGGPYGQQQQHHQQGHSQRPPGPPPDGYDIYGYPIGSGHQTRNQGSHEIHEIPSGTQQFGHGAPEGYGFQYSNCSGRRKALLIGINYLGQDAELHGCINDTKNVSAFLVENYGYKREDMVILTDDATNPLLQPTKENILRAMQWLVAGAQPNDALFLHYSGHGGQTKDTDGDEDDGYDEVIYPVDFKTAGHIVDDQIHDTVVKPLQPGVRLTAIFDSCHSGSVLDLPYIYSTKGVIKEPNLAKEAGQGLLAAVGSYARGDIGGMASSLFSVAKTAFGGGNEAYERTKRTKTSPADVIMWSGSKDDQTSADATIASQATGAMSWAFITAIKANPKQSYVQLLNSIRDVLETKYTQKPQLSSSHPIDVDMLFVM

casA

Metacaspase-1A

435 amino acids

Involved in cell death (apoptosis).

Belongs to the peptidase C14B family.

47.607 kDa

MQNHHHQQSSYGGGYPGQAYREQHPPPNPYGYGQPSPQPGYGAPPPHNGYATAVGIRPAAATYWKRGVQWKTAWYVIAFGAGRNASALESVKYAAADTCNTGMNQYQNPYSHGHQGGPPPPPTDPVAFGHGAPQGYSFQYSRCTGKRKALLIGINYFGQKGQLRGCINDVKNMSTYLNQNFGYAREDMVLLTDDQQNPMSQPTKANILRAMHWLVKDAQPNDSLFFHYSGHGGQTPDLDGDEEDGYDEVIYPVDFRQAGHIVDDEMHRIMVRPLRPGVRLTAIFDSCHSGSALDLPYIYSTQGILKEPNLAKEAGQGLLGVVSAYARGDMGGMVSTAVGFLKRATKGDEAYTRSKQTKTSPADVIMWSGSKDSQTSQDAQIAGQATGAMSWAFITALRKNPQQSYVQLLNSIRDELATKYSQKPQLSCSHPLGKH

casA

Metacaspase-1

432 amino acids

Involved in cell death (apoptosis).

Belongs to the peptidase C14B family.

47.735 kDa

MEVMDHHHHTSSTRPNPTTRRMNFFLPNAIHMDSHLLYYRPQPGYGAPPPQGGYGYPQPPPPQQPYGYSQPPPQQYGGYNGVPPNAPQYGRPGMPSVNSNAYINGNQNAPPPPPQGMHSFGQGAPQNYAFQYSNCTGRRKALLIGINYFGQRGQLRGCINDVKNMSSYLHENFGYQRDDMVILTDDQQNPMSQPTKQNILRAMHWLVKDARPNDSLFFHYSGHGGQTKDLDGDEEDGYDEVIYPVDFRQVGHIVDDEMHRIMVQPLQPGVRLTAIFDSCHSGTALDLPYVYSTQGVLKEPNLAKEAGQGLLGVISSYSQGDMSGVASNLMGFFKKATTGDDAYNKTLATKTSPADVVMWSGSKDDQTSADATIAAQATGAMSWAFITAMKKNPQQSYVQLLNSIRDELATKYTQKPQLSCSHPLSMVPPLLL

casA

Metacaspase-1

432 amino acids

Involved in cell death (apoptosis).

Belongs to the peptidase C14B family.

47.735 kDa

MEVMDHHHHTSSTRPNPTTRRMNFFLPNAIHMDSHLLYYRPQPGYGAPPPQGGYGYPQPPPPQQPYGYSQPPPQQYGGYNGVPPNAPQYGRPGMPSVNSNAYINGNQNAPPPPPQGMHSFGQGAPQNYAFQYSNCTGRRKALLIGINYFGQRGQLRGCINDVKNMSSYLHENFGYQRDDMVILTDDQQNPMSQPTKQNILRAMHWLVKDARPNDSLFFHYSGHGGQTKDLDGDEEDGYDEVIYPVDFRQVGHIVDDEMHRIMVQPLQPGVRLTAIFDSCHSGTALDLPYVYSTQGVLKEPNLAKEAGQGLLGVISSYSQGDMSGVASNLMGFFKKATTGDDAYNKTLATKTSPADVVMWSGSKDDQTSADATIAAQATGAMSWAFITAMKKNPQQSYVQLLNSIRDELATKYTQKPQLSCSHPLSMVPPLLL

casA

Metacaspase-1

431 amino acids

Involved in cell death (apoptosis).

Belongs to the peptidase C14B family.

47.16 kDa

MEAMEHQTSSTRPNPTTRRIKLPPLYAVLLELSLTLISPQPAYGAPPPQGGGYGYHQPPPPQQPYGYSQPPPQQYGGYNGVPPNAPQYGRPGMPSVNSNAYTNGNQNAPPPPPQGMHAFGQGAPQGYAFQYSNCTGKRKALLIGINYFGQRGQLRGCINDVKNMSSYLHENFGYQRDDMVLLTDDQQNPMSQPTKQNILRAMHWLVKDARPNDSLFFHYSGHGGQTKDLDGDEEDGYDEVIYPVDFRQVGHIVDDEMHRIMVQPLQPGVRLTAIFDSCHSGTALDLPYVYSTQGVLKEPNLAKEAGQGLLGVISSYSQGDMSGVASNLMGFFKKATTGDDAYNKTLATKTSPADVIMWSGSKDDQTSADATIAAQATGAMSWAFITAMKKNPQQSYVQLLNSIRDELATKYTQKPQLSCSHPLSMFSPLAL

casA

Metacaspase-1

431 amino acids

Involved in cell death (apoptosis).

Belongs to the peptidase C14B family.

47.16 kDa

MEAMEHQTSSTRPNPTTRRIKLPPLYAVLLELSLTLISPQPAYGAPPPQGGGYGYHQPPPPQQPYGYSQPPPQQYGGYNGVPPNAPQYGRPGMPSVNSNAYTNGNQNAPPPPPQGMHAFGQGAPQGYAFQYSNCTGKRKALLIGINYFGQRGQLRGCINDVKNMSSYLHENFGYQRDDMVLLTDDQQNPMSQPTKQNILRAMHWLVKDARPNDSLFFHYSGHGGQTKDLDGDEEDGYDEVIYPVDFRQVGHIVDDEMHRIMVQPLQPGVRLTAIFDSCHSGTALDLPYVYSTQGVLKEPNLAKEAGQGLLGVISSYSQGDMSGVASNLMGFFKKATTGDDAYNKTLATKTSPADVIMWSGSKDDQTSADATIAAQATGAMSWAFITAMKKNPQQSYVQLLNSIRDELATKYTQKPQLSCSHPLSMFSPLAL

casA

Metacaspase-1A

429 amino acids

Involved in cell death (apoptosis).

Belongs to the peptidase C14B family.

47.379 kDa

MQHHHQGSYGGGGGGGGYPGQAYREQNPYGYGQQSPQQGYGAPQQHNGYNQPPSGYGQPQHNGGQMYGQRQQGMWLRVRIASRDRKFLTFALGQYQNHYSHPHQGGPPPPPSEPVAFGHGAPQGYNFQYSRCTGKRKALMIGINYFGQKGQLRGCINDVKNMSTYLNQNFGYAREDMVLLTDDQQNPMSQPTKANILRAMHWLVKDAQPNDSLFFHYSGHGGQTPDLDGDEEDGYDEVIYPVDFRQAGHIVDDEMHRIMVQPLRPGVRLTAIFDSCHSGSALDLPYIYSTQGILKEPNLAKEAGQGLLGVVSAYARGDMGSMVSTAVGFLKRAAKGDEAYERTKQTKTSPADVIMWSGSKDSQTSQDAQIAGQATGAMSWAFISALRKNPQQSYVQLLNSIRDELATKYTQKPQLSCSHPLDTNLLYVM

casA

Metacaspase-1A

419 amino acids

Involved in cell death (apoptosis).

Belongs to the peptidase C14B family.

46.374 kDa

MHHQQSSYGGGYPGQAYRQQQPNNAYGYGQPSPQPYGSHHNGYNSPQQNYGPPSGGHMYQQQSAYQNSYNQGGHGIPARPPDQPVSFGQGAPQEYAYRYSACTGTRKALLIGINYFNQKGQLRGCINDVKNMSTYLHENFGYPRENMVLLTDDQQNPKSQPTKANILRAMHWLVKDAKPNDSLFFHYSGHGGQTPDLDGDEDDGYDEVIYPVDFRQAGHIVDDEMHRIMVNPLQPGVRLTAIFDSCHSGSALDLPYIYSTQGILKEPNLAKEAGQGLLGVVSAYARGDMGSMVSTAVGFFKKATKGDEVYERNKQTKTSGADVIMWSGSKDDQTSQDAQIQGQATGAMSWAFISALRKNPQQSYVQLLNSIRDELSTKYTQKPQLSCSHPLGDLIDVPVLGSGFIWFWVLSIFQCQATK

casA

Metacaspase-1A

413 amino acids

Involved in cell death (apoptosis) (By similarity). Required for the apoptotic-like loss of membrane phospholipid asymmetry at stationary phase and facilitates growth under conditions of endoplasmic reticulum stress.

Belongs to the peptidase C14B family.

45.199 kDa

MQNHHHQQSSYGGGYPGQAYREQHPPPNPYGYGQPSPQPGYGAPPPHNGYGQPPSGYGQPPPPTGNAVYGGRQPGMNQYQNTYSHGHQGGPPPPPTDPVAFGHGAPQGYSFQYSRCTGKRKALLIGINYFGQKGQLRGCINDVKNMSTYLNQNFGYAREDMVLLTDDQQNPMSQPTKANILRAMHWLVKDAQPNDSLFFHYSGHGGQTPDLDGDEEDGYDEVIYPVDFRQAGHIVDDEMHRIMVRPLRPGVRLTAIFDSCHSGSALDLPYIYSTQGILKEPNLAKEAGQGLLGVVSAYARGDMSGMVSTAVGFLKRATKGDEAYTRSKQTKTSPADVIMWSGSKDSQTSQDAQIGGQATGAMSWAFITALRKNPQQSYVQLLNSIRDELATKYSQKPQLSCSHPLDTNLLYVM

casA

Metacaspase-1A

413 amino acids

Involved in cell death (apoptosis) (By similarity). Required for the apoptotic-like loss of membrane phospholipid asymmetry at stationary phase and facilitates growth under conditions of endoplasmic reticulum stress.

Belongs to the peptidase C14B family.

45.199 kDa

MQNHHHQQSSYGGGYPGQAYREQHPPPNPYGYGQPSPQPGYGAPPPHNGYGQPPSGYGQPPPPTGNAVYGGRQPGMNQYQNTYSHGHQGGPPPPPTDPVAFGHGAPQGYSFQYSRCTGKRKALLIGINYFGQKGQLRGCINDVKNMSTYLNQNFGYAREDMVLLTDDQQNPMSQPTKANILRAMHWLVKDAQPNDSLFFHYSGHGGQTPDLDGDEEDGYDEVIYPVDFRQAGHIVDDEMHRIMVRPLRPGVRLTAIFDSCHSGSALDLPYIYSTQGILKEPNLAKEAGQGLLGVVSAYARGDMSGMVSTAVGFLKRATKGDEAYTRSKQTKTSPADVIMWSGSKDSQTSQDAQIGGQATGAMSWAFITALRKNPQQSYVQLLNSIRDELATKYSQKPQLSCSHPLDTNLLYVM

casA

Metacaspase-1

404 amino acids

Involved in cell death (apoptosis).

Belongs to the peptidase C14B family.

44.598 kDa

MHHHHQQPSYGSGYPGQAYRQQQNPYPQYGHPSPQPYPPQNGYSHPSSGYPPSPAPPNGGQMYHGRQPSYPPNQYPPAHGGPTAPPTNPQAFGHGAPQGYNFQYSRCTGKRKALLIGINYFGQKGQLRGCINDVKNMSTYLNQNFGYAREDMVILTDDQQNPMSQPTKANILRAMHWLVKDAQPNDSLFFHYSGHGGQTPDLDGDEDDGYDEVIYPVDFRVAGHIVDDEMHRIMVKPLQPGVRLTAIFDSCHSGSALDLPYIYSTQGILKEPNLAKEAGQGLLGVISSYARGDMGGMMSTAVGFLKKAAKGDEAYQRTKQTKTSPADVIMWSGSKDDQTSQDAQIAGQATGAMSWAFITAMRKNPQQSYVQLLNSIRDELSTRYTQKPQLSSSHPLDVNLLYVM

casA

Metacaspase-1

404 amino acids

Involved in cell death (apoptosis).

Belongs to the peptidase C14B family.

44.598 kDa

MHHHHQQPSYGSGYPGQAYRQQQNPYPQYGHPSPQPYPPQNGYSHPSSGYPPSPAPPNGGQMYHGRQPSYPPNQYPPAHGGPTAPPTNPQAFGHGAPQGYNFQYSRCTGKRKALLIGINYFGQKGQLRGCINDVKNMSTYLNQNFGYAREDMVILTDDQQNPMSQPTKANILRAMHWLVKDAQPNDSLFFHYSGHGGQTPDLDGDEDDGYDEVIYPVDFRVAGHIVDDEMHRIMVKPLQPGVRLTAIFDSCHSGSALDLPYIYSTQGILKEPNLAKEAGQGLLGVISSYARGDMGGMMSTAVGFLKKAAKGDEAYQRTKQTKTSPADVIMWSGSKDDQTSQDAQIAGQATGAMSWAFITAMRKNPQQSYVQLLNSIRDELSTRYTQKPQLSSSHPLDVNLLYVM

casA

Metacaspase-1A

404 amino acids

Involved in cell death (apoptosis).

Belongs to the peptidase C14B family.

44.268 kDa

MNPHHSHHHSSYGGGGYPGQAYRQQQPPSNPYQYNQPSPQPYQGSQPPQNGYNGGYPAASQGPMYGGRPGIADVYHNSYNQGNHSAPAPPPSDPVSFGQGAPQGYNFQYSRCTGKRKALLIGINYFNQKGQLRGCINDVKNMSTYLNQNFGYAREDMVVLTDDQQNPMSQPTKANILRAMHWLVKDAQPNDSLFFHYSGHGGQTPDLDGDEDDGYDEVIYPVDFRAAGHIVDDEMHRIMVKPLQPGVRLTAIFDSCHSGSALDLPYIYSTQGILKEPNLAKEAGQGLLGVVSAYARGDMSSMMSTAVGFFKKATKGDEAYERTIQTKTSPADVVMWSGSKDDQTSQDAQIAGQATGAMSWAFISALRKNPQQSYVQLLNSIRDELSAKYTQKPQLSCSHPLVAL

casA

Metacaspase-1A

403 amino acids

Involved in cell death (apoptosis).

Belongs to the peptidase C14B family.

44.206 kDa

MQHHHHSSYGGGGGGYPGQAYRQQQPYYGQPSPQPYAQPPPPNYQRPSGYGPPPSGGHMYQQGPPAPYQQHNSYQGGHGRPAPPPTDPVAFGHGAPQGYNFQYSRCTGKRKALLIGINYFGQKGQLRGCINDVKNMSTYLNQNFGYAREDMVLLTDDQQNPMSQPTKANILRAMHWLVKDAQPNDSLFFHYSGHGGQTPDLDGDEDDGYDEVIYPVDFRVAGHIVDDEMHRIMVNPLKPGTRLTAIFDSCHSGSALDLPYIYSTQGILKEPNLAKEAGQGLLGVVSAYARGDMGSMVSTAVGFLKKAAKGDEAYERTKQTKTSPADVIMWSGSKDSQTSSDAQIQGQATGAMSWAFISALRKNPQQSYVQLLNSIRDELATKYSQKPQLSCSHPLDVNLLYVM

casA

Endoglucanase 1

359 amino acids

CMCase I preferentially hydrolyzes carboxymethyl cellulose (CMC).

Belongs to the glycosyl hydrolase 6 (cellulase B) family.

36.515 kDa

MENPRTTPTPTPLRRRRSERRARGGRVLTALTGVTLLAGLAIAPAATGASPSPAPPASPAPSADSGTADAGTTALPSMELYRAEAGVHAWLDANPGDHRAPLIAERIGSQPQAVWFAGAYNPGTITQQVAEVTSAAAAAGQLPVVVPYMIPFRDCGNHSGGGAPSFAAYAEWSGLFAAGLGSEPVVVVLEPDAIPLIDCLDNQQRAERLAALAGLAEAVTDANPEARVYYDVGHSAWHAPAAIAPTLVEAGILEHGAGIATNISNYRTTTDETAYASAVIAELGGGLGAVVDTSRNGNGPLGSEWCDPPGRLVGNNPTVNPGVPGVDAFLWIKLPGELDGCDGPVGSFSPAKAYELAGG