cas4-cas1

CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion

580 amino acids

CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). The Cas4 region acts as a ssDNA exonuclease, while the Cas1 region acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).

In the C-terminal section; belongs to the CRISPR-associated endonuclease Cas1 family.

63.24 kDa

MAPSDTPPSAEDLPSQGELALFAPPATAEDALVPASMVNAWIYCPRLAVLEWGRGEKARSVDLIAGLRAHQATESGPTPALPDPMVLREDQSLKTRRLSLSSERLGLTAELDLLDVEEGMVIPVEIKVGKRPSVDEGAYLPERAQVCAQALLLREAGYTCLEGALWFAESRERVTVDLTEALVTATLVATSDLRLTVASGRLPPPLDHSAKCPRCSLLPICLPDEIAWFRKGSIARTPPPPASPALPLYGQTPGARIGKKDYTLVIQVEGEADRSLALDEISEVVLAGPVSLTTPAIHELLRREIPVAWMSSGFWFLGSTGGQGPRSAAVRTAQYALAGDERRRQAFARDLVSAKIRNGRTLLRRNWRGAEAERQIALDRLARLAERATTAETTACLLGIEGEAAAVYFRAFPQLFTQAVTTLPAFAFERRNRRPPADPVNACLSLCYAVLTRTLSSALSIAGLDPWKGFYHTERPGRPALALDLIESFRPVLADSTVLMVLNNGEIGTNDFLYAGGGCALKPNARRGLIAAYERRLDQETTHPVFGYQLSMRRLIQVQARLLARFVSGDIPRYPHYCPR

cas4-cas1

CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion

568 amino acids

CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). The Cas4 region acts as a ssDNA exonuclease, while the Cas1 region acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).

In the C-terminal section; belongs to the CRISPR-associated endonuclease Cas1 family.

62.762 kDa

MSVVVTRYRGGGPQYMNASSTSPKPVVGEPSIRTHALHALAYCERLFYLEEVEELRVADAAVFAGRRLHVQLQEEGEHVELELASEALGLHGRVDAVKTREGTLVVYEHKRGRHAPGGDAPEAWPSDRLQAGAYALLVEERFPGAPVECRVRYHQTDTTVRFPLDAALRGAVVAAVARARLLRASRERPPVTQEERKCAKCSLAPVCLPEEERQVVGEERPRLFPEDDVRQVLHVATPGTRVGRAAEELVVTPPEGEGAPSRQPGRMVSALIAHGAVQVSAQALAYCVENDIGVHWFTSGGRYLGGLGGGAGNVHRRLRQFEALRQASVCLGLARRLVAAKLEGQLRFLLRASRGDSESRQVLASAVRDLRALLPKCEEAPSLEVLLGLEGAGAARYFGALPYLQGEDVDTRLRFEGRNRRPPRDRFNAVLGFLFGLVHREVEAAIRAVGLDVAFGFYHQPRGTAGPLGLDVMELFRVPLADMPLVASVNRRAWDADADFEVTSEHVWLSKAGRAKAIELYERRKRETWKNNVLGYSLSYARLVELEVRLLEKEWTGKPGLFATFRLR

cas4-cas1

CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion

559 amino acids

CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). The Cas4 region acts as a ssDNA exonuclease, while the Cas1 region acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).

In the C-terminal section; belongs to the CRISPR-associated endonuclease Cas1 family.

62.515 kDa

MAETDGSIPLIPVRMLNEHVYCPRLAYLMWVQGEFSHNEFTVDGVIRHRRVDAGGGVLPSETQEDSRIHARSVSLSSERLGITAKIDLVEGEGAYVSPVDYKRGKRPHVAGGAYEPERVQLCAQGLLLREHGFASDGGALYFVASRERVPVAFDDELIGRTLAAIDEMGRTALSGTMPPPLEDSPKCPRCSLVGICLPDEVRFLSHLSVEPRPIIPADGRGLPLYVQSPKAYVRKDGDCLVIEEERVRVAEARLGETSQVALFGNATLTTAALHECLRREIPVTWLSYGGWFMGHTVSTGHRNVETRTYQYQRSFDPETCLNLARRWIVAKIANCRTLLRRNWRGEGDEAKAPPGLLMSLQDDMRHAMRAPSLEVLLGIEGASAGRYFQHFSRMLRGGDGEGMGFDFTTRNRRPPKDPVNALLSFAYAMLTREWTVALAAVGLDPYRGFYHQPRFGRPALALDMMEPFRPLIADSTVLMAINNGEIRTGDFVRSAGGCNLTDSARKRFIAGFERRMEQEVTHPIFKYTISYRRLLEVQARLLTRYLSGEIPAYPNFVTR

cas4-cas1

CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion

541 amino acids

CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity). The Cas4 region acts as a ssDNA exonuclease, while the Cas1 region acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).

In the C-terminal section; belongs to the CRISPR-associated endonuclease Cas1 family.

61.58 kDa

MGIHSLLYCERLFYLEEVEGILVADDRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHKRGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKGLSTSTNRPPVAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPIQEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQLRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDPFNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKVWLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR