Function
Serves as the scaffold for the assembly of a complex that links key players in the nucleation and termination of actin filament assembly with a ubiquitous barbed end-directed motor. This complex is composed of at least capping proteins (acpA and acpB), the Arp2/3 complex, type I myosins (myoB and myoC) and carmil. It has at least a modest ability to activate Arp2/3-dependent actin nucleation. CARMIL localizes along with the Arp2/3 complex, myoB, and myoC in the leading edge of cells and it plays a significant role in the structure and function of these actin-rich cellular extensions.
Sequence
MSEEISPNDRKFITNLLTQKNQESLLLSIGDKISKKKNKKPSKRIILITKNRIFFLKPSQNKVKKDIHLLDIQEIKSSTSNEFTIVAKVDNKQFSYGLITNKTDEIINQIRVTFNHQFFGCPEESTFKCTDIKDSRLVEIEQKDLPCGGFVETYQSICDHLGVPPRDDICWDMTNIISSKNIRSFNIGEIELPTSAGDTIRCLLGALKYNNYFKSFNFNNYTFNKEQFGYLAEVLKCNSTVEDLSLNNVGLKHDTMPIIATALSSNKNLALTAIDISNNQIEDKGMTAFSSYVASSLRGIASLDVSNTNCNKAGISVLTNALKKNIKMSSTLSYLNLSGNKMEADGSAGLSSFLASPNTLKTLNISNTTPSMETIVGALVIGCAELKTIDISDNKLTKKEVPHLVRFIGASSTLKHFNLSGTKVPVENLKELVVAITSNIYLQDVVLDLKNNDLGIAGARMLASLATDKLSNVIYLDVSENDFGDEGVSVICDGFVGNSTIKKLILNGNFKQSKTKSRPSAIESVISLLESECPLETLHMTVGNSKSPLKADILSLIYSLATNSSLLELDISGHQMGPKGAIGLGKALQTNKTLHTLIWDDNLTTAIGFAGFQVGLERNLTLKNMPTPLNDIIQCHREPKFQQIWKEIDSCINRNQSPTRAFEGNGGNSIGATNLSFLASGQQQGVEKLLNKIKSIGRKVTDPNNILIVKDAESTEKVIGGIHLIKESIHASLEMELNQKLKDFVQVVNDVINAKKNEMTQQILESMQNTFQSMDGPTIKRLATTIQYGSKDVDEQQIHSTLVKGAGAELSSRAHECFISALDIASDYTYEKITIGLDSVFKDLILEESQAQNEASGATPIPDSPVPTRSPQPTSPPITPQPTPTTNVPPVTAPRTGAAAPLKPANPPPVSTTTTPPVSTTPKPTQPVSKFGAKLSANSAVAEAIARNMGGGAPPIRKPVAPEPEPEPVTPTKDVTPLKSKPVVAPRSTPTTSTPTKTPVKKPSGPSVPGSLSDAPESDSAELTHVTASRPHIASKRKPPTRRPRPPTEN