Protein
Transcriptional regulator calD
Organism
Penicillium decumbens
Function
Transcription co-regulator that might be involved in the regulation of the expression of the gene cluster that mediates the biosynthesis of calbistrins and related compounds such as decumbenones. Calbistrin A is a secondary metabolite with an interesting structure that was recently found to have bioactivity against leukemia cells. It consists of two polyketides linked by an ester bond: a bicyclic decalin containing polyketide and a linear 12 carbon dioic acid structure.
Sequence
MFGLFRSKAPEAPPKHPTDTIIPLNAADDTEVLRSVVVVLSYRFDDVLDPVKLKSSFEKLLDRPGWRKIGARLRLNDNGRLEYHIPERYDEKRPIVTWSHVSHNVSVLKHPLSSKLPRASARPAVVGDPNDFDELTSSPEAPKTLHDYLTRDVPQLCLHVVSFTDSTLVSISLPHTLTDGTGGAQIYRCWALVLQDRDDEVPPFHGYDSDPLATFGETSSQPYMYDPKLLTGWRKWLFILYQVYDGWRYRTSSRIVCVPGPYLAAQRKKAIEEIRAETGNDKAFVSDNDVLTAWFTRLAVGHYPRNSNLTVRIMNAFALASVLGNDRLPSTKAFISNAATEIYTFLSVRDFFTKPLSYAAYAIRRSMMEGGTREQVEALQAVKKQTLAREGHTWPIFGDASMEMMSYSNWTKGKYFETDFSAAIVKEGFAREARAEKPGFASMVQFNAWSTKFDLRNLMPIMGKDAAGNYWLQGPLRDVVWKRIEKELREEPLQ