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bud32

Gene
BUD32
Protein
EKC/KEOPS complex subunit BUD32
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
296 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
33.882 kDa
Sequence
MTDHLIAKVQEHVPNIPLKIISQGAEALVFETSVHPYYNYNSSEKHHESPSLHNHTTFIIKYRPTKPYRHPKIDLQINKSRTIGEVKFMYKLSKLNIACPNIISTDFNNGIIWMECLGSKLPNGTISSFKNWLWYLESQEKEDPSINLHDDDQVELVCQKVGQLIGRLHLNDMIHGDLTSSNIILTEVDTKKNEDTDANNSSVYFEPALIDFGLSSFSGLAEDKAVDLYVLERAILSTHSNYADKLNGWLLEGYQQIHDSIEFNKTKQQLGKSKLKDTIKRLEDVRLRGRKRSMLG

Gene
BUD32
Protein
EKC/KEOPS complex subunit BUD32
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
Length
289 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
31.67 kDa
Sequence
MAASTPLLSRGTLIKQGAEAKVYALPSLFPEPTTYHPGSSSSFSAASPTPVILKHRFTKTYRHPTLDASLTSQRLTFEARALARAAKAGVTVPKVVWVDEKAGVIGMERIEGWSVREILGGGAEGEVEVIEEQEIEEDVENKAEDSAVREEPEGPESEGLKALKNLGVTQEHLMRSIGAALARLHKTMIIHGDLTTSNMMVRLTPGGSGPYEIVLIDFGLSSQAQFPENYAVDLYVLERAFASTHPRSEKLYAGVLETYAEGLGEKKWKPIQIKLKDVRRRGRKRDMTG

Gene
BUD32
Protein
EKC/KEOPS complex subunit BUD32
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
289 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
31.67 kDa
Sequence
MAASTPLLSRGTLIKQGAEAKVYALPSLFPEPTTYHPGSSSSFSAASPTPVILKHRFTKTYRHPTLDASLTSQRLTFEARALARAAKAGVTVPKVVWVDEKAGVIGMERIEGWSVREILGGGAEGEVEVIEEQEIEEDVENKAEDSAVREEPEGPESEGLKALKNLGVTQEHLMRSIGAALARLHKTMIIHGDLTTSNMMVRLTPGGSGPYEIVLIDFGLSSQAQFPENYAVDLYVLERAFASTHPRSEKLYAGVLETYAEGLGEKKWKPIQIKLKDVRRRGRKRDMTG

Gene
BUD32
Protein
EKC/KEOPS complex subunit BUD32
Organism
Coccidioides immitis (strain RS)
Length
287 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
32.238 kDa
Sequence
MTEEFTPPPLPPPFTSNKTPPVLLAQGAEARLYKTDFLNPSFPAALKFRPSKPYRHPILDRRLTRQRVLQEARCLVKLLKEGIPVPGVLSVDWNTGQGEDETGNGGAWLLMEWIEGPAVRQVVNHWEKWMKHCESATKGNNSGMNENFERSAEEDIRSLLRRIGRVIGALHKAGVIHGDLTTSNLILRGQSNENTTNIDPHSTTLKPNLEGEIVLIDFGLASQSVQDEDRAVDLYVLERAFGSSHPRTEIFFDEVLKAYRESFKGASSVLETLKKVRMRGRKRSMVG

Gene
bud32
Protein
EKC/KEOPS complex subunit bud32
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
285 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
31.806 kDa
Sequence
MPPTNRPPPFSTILSSASLPSYSSTDELTPIYQGAEAHLYKTTFLSPSQPAALKIRPSKPYRHPILDRRLTRARILQEARCLQKLVKEGVSVPALLGVDWEPSAGDGSSWLVMEWIEGEPVRVILEEWEAYLKGIEREKRLGLGEGVQGSEEEKVRGLMRRIGRAVGGLHRAGVIHGDLTTSNLMLRPLGSADTTETIEERDQSPSMAGEVVMIDFGLAMQSSQDEDRAVDLYVLERAFGSSHPRTERFFEEVLVGYRESYKGAVSALKRLEDVRMRGRKRSMIG

Gene
bud32
Protein
EKC/KEOPS complex subunit bud32
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Length
277 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
31.061 kDa
Sequence
MSSAEPYTPPPLPSPFTNTTPPPQLLTQGAEAHLYKTVFLSPSTPAALKVRPSKPYRHPILDRRLTRQRILQEARCLVKLVREGVNVPAVLALDWEGQNTEKGFGGAWLMMEWVEGLVVRVVLERWERWMKRNQGSSGAEELKEEENWVRDLLRRIGRAVGALHKAGVIHGDLTTSNLILRPPGHVGEQADTGESSPSMEGDVVLIDFGLASQSLQDEDRAVDLYVLERAFGSTHPRTEPFFEEVLNGYRESYKGASSALKRLEDVRMRGRKRSMIG

Gene
bud32
Protein
EKC/KEOPS complex subunit bud32
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
277 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
30.938 kDa
Sequence
MASTDPYTPPPLPSPFTNTTPPPQLLTQGAEAHLYKTVFLSPSAPAALKVRPSKPYRHPILDRRLTRQRILQEARCLVKLVREGVNVPAVLALDWEGQSGEKGFGGAWLMMEWIEGMVVRVVLERWEKYMKRNQAGLGAEEFEKEEARVRDLMKRIGHAVGALHKAGVIHGDLTTSNLILRPPTRAEQQPAADETNPSMEGDVVLIDFGLASQSLQDEDRAVDLYVLERAFGSTHPRTEPLFTEVLSGYKESYKGASSALKRLEEVRMRGRKRSMIG

Gene
bud32
Protein
EKC/KEOPS complex subunit bud32
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
272 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
30.044 kDa
Sequence
MSQDPYTPPPLPKPFTNTTPPPTLLTQGAEAHLYKTIHLNTNTPAALKIRPSKPYRHPILDRRLTRQRILQEARCLVKLVREGVNVPAVLALDWEGQGGENGNGGAWLLMEWIEGLVVRVVFERWEAFIKASGGSLGEKELRREEEKVRGLMRGIGGVVGGLHKAGVIHGDLTTSNLILRTGDVDIKDGESPAMVGDVVLIDFGLAGQSSSEEDRAVDLYVLERAFGSTHPQAEKFFEEVLEGYKDSYKGAAVTLKRLQDVRMRGRKRSMIG

Gene
BUD32
Protein
EKC/KEOPS complex subunit BUD32
Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)
Length
267 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
29.394 kDa
Sequence
MAAADDAQFPPPKVLTYPASTPPTLITQGAEGRLYKTTHLTRDRPCALKYRPPKPYRHPVLDARLTKARLSSEAKVLERCWREGVPVPAVYAMDPAAGWMMMEWIEGIPVRVGINEWLGDRPEEGAEIPQVADETPIVDLMKRIGAAIGALHKTGVVHGDLTTSNMMLRPRGFNPVDGAPGDEGKAGSVEGDVVLIDFGLATQSMSDEDRAVDLYVLERAFASTHPRAERLFATLLESYKSTFKKASSVLIKLEDVRMRGRKRSMLG

Gene
BUD32
Protein
EKC/KEOPS complex subunit BUD32
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
266 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
30.718 kDa
Sequence
MSQEIVDRVRNYLSPNIPVTPISQGAEAVVFTTSVHPYLPENCNSNEKYIIKYRSPKRYRHPVIDKSLTKHRTLGEARLLSKLYTIEGLHVPKLIACDAYNGYLWLEFLGEDLPENFGYSNLKNFLWMYDAKNDPYCEVVKRALIEVGEQIGKLHWNDYCHGDLTSSNIVMVHSDTDSHHWVPHLIDFGLGSTTTMVEDKGVDIYVLERAILSTHSQHAEQYIEWMLDGFKSVYEKNGKLGKKKLDELLKRFAEVRLRGRKRSMIG

Gene
BUD32
Protein
EKC/KEOPS complex subunit BUD32
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
263 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
29.818 kDa
Sequence
MSAEIIASIADVLTDNIPLTPISQGAEAVVFTSPVHPYLPKNRTDGDDKLYILKYRPEKKYRHPVIDKTLTKHRTLGESRLLAKLRLIDGLNVPKLIGCDPYHGCIWLEFLGEDLPNGHGFSNLKNFLWMNASDPYSDLVRDTMINVGKQIGLMHWNDYCHGDLTTSNIVLVRAGEDWQPYLIDFGLGSISTLVEDKGVDLYVLERAIISTHSSFANRYNLWVLEGFKSVFESHGKAGLGKYKDLIRRFEEVRLRGRKRSMIG

Gene
BUD32
Protein
EKC/KEOPS complex subunit BUD32
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
262 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
29.174 kDa
Sequence
MTTTTATATADPAEQAHQFPLPKILEYPASTPPILITQGAEGRLYKTTYLLPDIPCALKYRPPKPWRHPILDQRLTKHRILSEARILAKCRRDGVRVPAVYAVDESAGWLMLEWVSGGPVRKSINERLGNRTEGIENDAELKDLMRRIGTAIGNMHKVGIVHGDLTTSNMMLEPLANPQDDNPLHGELVIIDLGLSSGSISDEDRAVDLYVLERAFGSTHPRAECVFSEVLDAYGQTFKQAKVVLKKLEDVRMRGRKRSMLG

Gene
BUD32
Protein
EKC/KEOPS complex subunit BUD32
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
261 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. Important for bud site selection.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
29.936 kDa
Sequence
MTQEFIDKVSSYLTPDVDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIMEGFEEVYREQGAKGAKKLKEVTKRFEEVRLRGRKRSMLG

Gene
BUD32
Protein
EKC/KEOPS complex subunit BUD32
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
260 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
29.235 kDa
Sequence
MSAEVISRVSQIYGEGITLTPISQGAEAVIFTTTTHPYLPSTEGSSKYVVKYRPPKTYRHPSIDVALTKQRTLGEARLLGKLQQIKGLRVPKLLACDVYNGSIWMEFLGEDLPESRGFSNLKNFLWMCASEPYSPVVEATVRDVGCQIGLLHWNDYCHGDLTTSNIVLVRSGAEWAPHLIDFGLGSNSNLVEDKGVDLYVLERALASTHSAFAEKYFEWLMEGFTSVYQSHGEKGEQKLKELLRRFEEVRLRGRKRSMLG

Gene
BUD32
Protein
EKC/KEOPS complex subunit BUD32
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
260 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
29.991 kDa
Sequence
MTDHIVKKAQECLPNIPLTVISQGAEALVFYTDVHPYANEPYLQNRGKYVIKYRPSKPYRHPKVDSSITKSRTVGEVKFMYKLNKLNINSPRIISADYNNGIIWMEYIGYSLPNGDVSSFKNWLWYLERNNQDCTSESVEKMCFKVGQLIGKLHLHEMIHGDLTSSNILLNDDEPVLIDFGLSSYSGLAEDRAVDLYVLERAITSTHSVYAKEYNQWLLQGYEDVHKHKEFGKQGQKKLVEVLKKLDDVRLRGRKRSMLG

Gene
bud32
Protein
EKC/KEOPS complex subunit bud32
Organism
Dictyostelium discoideum
Length
252 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Bud32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit osgep (By similarity).
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
28.577 kDa
Sequence
MDANECSNSENSATTTIPKSASPSTTISTKVVKLDEIGILISQGAEAKTYETDLYGLKCIVKERFSKAYRHPILDQKISSKRILQEVRSLNKCKKKGIQVPSLYLVDIGNNRIYMEFIKGETVKHYLYKNQESTQHQNQIESIMKELGNQIGIIHEMNVIHGDLTTSNMLLRESTNELVFIDFGLSYTSNSVEDKAVDLYVLERAFISTHPNSEQLFQTILSNYELTSSNSKIVIQKLNQVRLRGRKKTCFG

Gene
BUD32
Protein
EKC/KEOPS complex subunit BUD32
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
248 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
27.804 kDa
Sequence
MITLPEQLEKLSKQENLIAQGAESLVYSAQHPYLPQQECIVKYRPKKPYRLPELDAQLSKHRTLAEARVLQKLALGDVEVPHLVFIDAKNGLIYMEKIEGLSVKQWIWNEEGDTEGGAQEAGDKSRSLPDGDVSSLKDTLVLVGQEIGKLHKSDIVHGDLTTSNVMLRDGKPVIIDFGLASVSTLAEDKAVDLYVMERAVLSTHPVHSQQYCDWLFEGYLAVVGKSQKEVMRKLEDVRQRGRKRSMLG

Gene
bud32
Protein
KEOPS complex subunit Bud32
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Length
220 amino acids
Function
Component of the KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Bud32 has ATPase activity in the context of the KEOPS complex and likely plays a supporting role to the catalytic subunit Kae1.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
26.343 kDa
Sequence
MKLIKQGAEAKIYLAEFSELYFDYPIKVIVKERIKKRYRIPEIDLKLRKERTIREARILRRAKEFGVNVPYVFEVDTKNMIIVMEYIEGERLKELLEKLPMEERLKVCREVGRQIGKLHEAGIVHGDLTTSNMILREGKVYFIDFGLAEFDDTIEAQGVDLHLLKRAMESTHYKWFERGFEEVLKGYIEIRGEDKGREIREKIREIELRGRYRERSWITQ

Gene
BUD32
Protein
EKC/KEOPS complex subunit BUD32
Organism
Enterocytozoon bieneusi (strain H348)
Length
203 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
23.778 kDa
Sequence
MILITSGAEAEIYESENMIIKRRVKKNYRIDELDSMLNKTRTKREVNIIKKLNALNIPSPMFYTTNKYDIVMEKIKGIPVKNILNNESLTSNQFLNKICAKTHKDILIEIGNIVYAMHNNNIIHGDLTTLNFIYSDKIHIIDFGLSFYSNKDEDKAVDLYLFEKSLISVHNEEFVSYFYSGYIVNETLNKKLLEIRKRGRKRE

Gene
BUD32
Protein
EKC/KEOPS complex subunit BUD32
Organism
Encephalitozoon cuniculi (strain GB-M1)
Length
197 amino acids
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
Similarity
Belongs to the protein kinase superfamily. BUD32 family.
Mass
21.847 kDa
Sequence
MGFHFQGAESIISADGETVVKKRARKAYRIEALDLKIINGRTKREAKILRKLEALGIPAPRLISTYGDTIVMEKVEGTVLKEMIDSSDNPGALFRDLGALVSRLHIADIIHGDLTTSNFIHGSKIYAIDFGLSYISRKDEDKAVDLYVFEKAVGCAHDAKFLEDFYCGYMGEGSESVLKKLGTVRLRGRKREAMAFG